Peripheral clock gene expression in CS mice with bimodal locomotor rhythms

Tsuyoshi Watanabe, Mayumi Kojima, Shigeru Tomida, Takahiro J. Nakamura, Takashi Yamamura, Nobuhiro Nakao, Shinobu Yasuo, Takashi Yoshimura, Shizufumi Ebihara

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


CS mice show unique properties of circadian rhythms: unstable free-running periods and distinct bimodal rhythms (similar to rhythm splitting, but hereafter referred to as bimodal rhythms) under constant darkness. In the present study, we compared clock-related gene expression (mPer1, mBmal1 and Dbp) in the SCN and peripheral tissues (liver, adrenal gland and heart) between CS and C57BL/6J mice. In spite of normal robust oscillation in the SCN of both mice, behavioral rhythms and peripheral rhythms of clock-related genes were significantly different between these mice. However, when daytime restricted feeding was given, no essential differences between the two strains were observed. These results indicate that unusual circadian behaviors and peripheral gene expression in CS mice do not depend on the SCN but rather mechanisms outside of the SCN.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalNeuroscience Research
Issue number4
Publication statusPublished - Apr 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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