TY - JOUR
T1 - Peripheral clock gene expression in CS mice with bimodal locomotor rhythms
AU - Watanabe, Tsuyoshi
AU - Kojima, Mayumi
AU - Tomida, Shigeru
AU - Nakamura, Takahiro J.
AU - Yamamura, Takashi
AU - Nakao, Nobuhiro
AU - Yasuo, Shinobu
AU - Yoshimura, Takashi
AU - Ebihara, Shizufumi
N1 - Funding Information:
We thank Nagoya University Radioisotope Center for its facilities. This research was supported in part by a Grant-in Aid from a Ministry of Education, Science and Culture to S.E.
PY - 2006/4
Y1 - 2006/4
N2 - CS mice show unique properties of circadian rhythms: unstable free-running periods and distinct bimodal rhythms (similar to rhythm splitting, but hereafter referred to as bimodal rhythms) under constant darkness. In the present study, we compared clock-related gene expression (mPer1, mBmal1 and Dbp) in the SCN and peripheral tissues (liver, adrenal gland and heart) between CS and C57BL/6J mice. In spite of normal robust oscillation in the SCN of both mice, behavioral rhythms and peripheral rhythms of clock-related genes were significantly different between these mice. However, when daytime restricted feeding was given, no essential differences between the two strains were observed. These results indicate that unusual circadian behaviors and peripheral gene expression in CS mice do not depend on the SCN but rather mechanisms outside of the SCN.
AB - CS mice show unique properties of circadian rhythms: unstable free-running periods and distinct bimodal rhythms (similar to rhythm splitting, but hereafter referred to as bimodal rhythms) under constant darkness. In the present study, we compared clock-related gene expression (mPer1, mBmal1 and Dbp) in the SCN and peripheral tissues (liver, adrenal gland and heart) between CS and C57BL/6J mice. In spite of normal robust oscillation in the SCN of both mice, behavioral rhythms and peripheral rhythms of clock-related genes were significantly different between these mice. However, when daytime restricted feeding was given, no essential differences between the two strains were observed. These results indicate that unusual circadian behaviors and peripheral gene expression in CS mice do not depend on the SCN but rather mechanisms outside of the SCN.
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U2 - 10.1016/j.neures.2005.12.009
DO - 10.1016/j.neures.2005.12.009
M3 - Article
C2 - 16442179
AN - SCOPUS:33644866234
SN - 0168-0102
VL - 54
SP - 295
EP - 301
JO - Neuroscience Research
JF - Neuroscience Research
IS - 4
ER -