Periodontal inflammation and insulin resistance - Lessons from obesity

F. Nishimura, Y. Murayama

Research output: Contribution to journalShort surveypeer-review

69 Citations (Scopus)


Recent attention has been focused on our understanding of the negative influences of oral chronic inflammation on systemic health. Successful periodontal treatment appears to have beneficial effects on the metabolic control of type 2 diabetes. Although type 2 diabetes is a multiple-risk-factor syndrome, lowered insulin sensitivity, called insulin resistance, is essential in developing the disease. Pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α), produced from adipose tissues in obese subjects, is known to play a predominant role in inducing insulin resistance. Therefore, it can be hypothesized that anti-infectious periodontal treatment may improve metabolic control of diabetes via improved insulin sensitivity by reducing peripheral TNF-α concentration. In this review, we summarize the nature of insulin resistance and discuss the mechanisms by which insulin sensitivity is influenced by chronic inflammation, such as in periodontal disease.

Original languageEnglish
Pages (from-to)1690-1694
Number of pages5
JournalJournal of Dental Research
Issue number8
Publication statusPublished - 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Dentistry


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