TY - JOUR
T1 - Pericentric inversion of chromosome 16 and eosinophilia in chronic myelomonocytic leukemia
AU - Miyamoto, Toshihiro
AU - Akashi, Koichi
AU - Hayashi, Shin
AU - Oogami, Akiko
AU - Okamura, Takashi
AU - Iwasaki, Hiromi
AU - Murakawa, Masahiro
AU - Harada, Mine
AU - Niho, Yoshiyuki
PY - 1997/4
Y1 - 1997/4
N2 - We report a case of myelodysplastic syndrome with bone marrow eosinophilia and the chromosomal abnormality, inv(16)(p13q22). Hematologic findings including monocytosis and trilineage myelodysplasia were consistent with chronic myelomonocytic leukemia, and numerous abnormal eosinophils were present in the bone marrow. Chromosomal analysis of all metaphase cells from peripheral blood and bone marrow revealed inv(16)(p13q22), which is well known characteristic of acute myelomonocytic leukemia with eosinophilia (M4Eo). Both monocytes and eosinophils in this case may be derived from common leukemic progenitors affected by inv(16)(p13q22).
AB - We report a case of myelodysplastic syndrome with bone marrow eosinophilia and the chromosomal abnormality, inv(16)(p13q22). Hematologic findings including monocytosis and trilineage myelodysplasia were consistent with chronic myelomonocytic leukemia, and numerous abnormal eosinophils were present in the bone marrow. Chromosomal analysis of all metaphase cells from peripheral blood and bone marrow revealed inv(16)(p13q22), which is well known characteristic of acute myelomonocytic leukemia with eosinophilia (M4Eo). Both monocytes and eosinophils in this case may be derived from common leukemic progenitors affected by inv(16)(p13q22).
UR - http://www.scopus.com/inward/record.url?scp=0030888130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030888130&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(96)00207-5
DO - 10.1016/S0165-4608(96)00207-5
M3 - Article
C2 - 9109936
AN - SCOPUS:0030888130
SN - 0165-4608
VL - 94
SP - 99
EP - 102
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
