Performance of a Honeycomb Monolith Bioreactor in a Gas-Liquid-Solid Three-Phase System

Koei Kawakami, Kyosuke Kawasaki, Fumihide Shiraishi, Koichiro Kusunoki

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52 Citations (Scopus)


The gas-liquid and liquid-solid mass-transfer rates in a monolith reactor were measured with three different channel sizes, i.e., 12, 31, and 62 cells/cm2, and at various gas and liquid flow rates. In the range of measurements, the volumetric coefficients for both mass-transfer steps were higher in the case of gas-liquid cocurrent upflow operation than in the downflow operation. The effect of channel size was less pronounced. The oxidation of glucose by immobilized glucose oxidase was investigated, and the characteristics of the monolith reactor were analyzed. The conversion of glucose was higher with the monolith reactor involving a larger number of channels, due to thinner walls leading to a reduction of resistance to internal diffusion of oxygen. Model calculation indicated that, in the upflow operation, the overall effectiveness factor of the reactor loaded with monolith 62 cells/cm2 was more than 0.3, while in the downflow operation the overall effectiveness factor was less than 0.1. It turned out that, in the latter operation, the conversion was influenced by incomplete wetting of the monolith wall.

Original languageEnglish
Pages (from-to)394-400
Number of pages7
JournalIndustrial and Engineering Chemistry Research
Issue number4
Publication statusPublished - Apr 1 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering
  • Industrial and Manufacturing Engineering


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