Peptide-Based Switching of Polymer Fluorescence in Aqueous phase

Hirotaka Ejima, Hiromi Kikuchi, Hisao Matsuno, Hirofumi Yajima, Takeshi Serizawa

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)


    The phage display method on water-soluble and commonly used poly-(2-methoxy-5-propyloxysulfonate-1,4-phenylenevinylene) (mpsPPV) were studied. mpsPPV was immobilized using a layer-by-layer (LbL) assembly technique with poly(diallyldimethylammonium chloride) (PDDA) to obtain water-insoluble polyelectrolyte multilayer films, with an outermost surface composed of mpsPPV, on a glass substrate. The assembly process and the stability of the obtained LbL films were monitored by quartz-crystal microbalance (QCM) measurement. A linear 12-mer peptide library solution was applied to this LbL film. The LbL film was considered to be stable throughout the phage display experiment, because the frequency shift was negligible after immersion in ethanol and Tris-buffered saline. It was suggested that π-π interactions were predominant between the peptide and mpsPPV.

    Original languageEnglish
    Pages (from-to)6032-6034
    Number of pages3
    JournalChemistry of Materials
    Issue number22
    Publication statusPublished - Nov 23 2010

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)
    • Chemical Engineering(all)
    • Materials Chemistry


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