TY - JOUR
T1 - PEG-silica-modified gold nanorods that retain their optical properties in tumor tissues
AU - Akiyama, Yasuyuki
AU - Niidome, Yasuro
AU - Mori, Takeshi
AU - Katayama, Yoshiki
AU - Niidome, Takuro
N1 - Funding Information:
This research was supported by a Grant-in-Aid of Scientific Research (B) (No. 22300158) and a Grant-in-Aid for Challenging Exploratory Research (No. 23650266) from the Japan Society for the Promotion of Science (JSPS).
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Gold nanorods modified with polyethylene glycol (PEG) chains via Au-S bonds form aggregates, and their absorption spectra broaden in tumor tissues. In contrast, the gold nanorods modified here via the crosslinking of PEG chains on the silica shell on gold nanorods showed enhanced permeability and retention effects and retained the optical properties of the original gold nanorods in tumor tissues.
AB - Gold nanorods modified with polyethylene glycol (PEG) chains via Au-S bonds form aggregates, and their absorption spectra broaden in tumor tissues. In contrast, the gold nanorods modified here via the crosslinking of PEG chains on the silica shell on gold nanorods showed enhanced permeability and retention effects and retained the optical properties of the original gold nanorods in tumor tissues.
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U2 - 10.1080/09205063.2013.823073
DO - 10.1080/09205063.2013.823073
M3 - Article
C2 - 23909685
AN - SCOPUS:84886090413
SN - 0920-5063
VL - 24
SP - 2071
EP - 2080
JO - Journal of Biomaterials Science, Polymer Edition
JF - Journal of Biomaterials Science, Polymer Edition
IS - 18
ER -