TY - JOUR
T1 - PEG-modified gold nanorods with a stealth character for in vivo applications
AU - Niidome, Takuro
AU - Yamagata, Masato
AU - Okamoto, Yuri
AU - Akiyama, Yasuyuki
AU - Takahashi, Hironobu
AU - Kawano, Takahito
AU - Katayama, Yoshiki
AU - Niidome, Yasuro
N1 - Funding Information:
This research was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (No. 16790106), and a Grant-in-Aid for Scientific Research in the Priority Area “Molecular Nano Dynamics” (No. 17034049) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2006/9/12
Y1 - 2006/9/12
N2 - Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems. Since gold nanorods stabilized with CTAB show strong cytotoxicity, we developed a technique to modify these with polyethyleneglycol (PEG) for medical applications. PEG-modification was achieved by adding mPEG-SH in the CTAB solution, then, excess CTAB was removed by dialysis. PEG-modified gold nanoparticles showed a nearly neutral surface, and had little cytotoxicity in vitro. Following intravenous injection into mice, 54% of injected PEG-modified gold nanoparticles were found in blood at 0.5 h after intravenous injection, whereas most of gold was detected in the liver in the case of original gold nanorods stabilized with CTAB.
AB - Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems. Since gold nanorods stabilized with CTAB show strong cytotoxicity, we developed a technique to modify these with polyethyleneglycol (PEG) for medical applications. PEG-modification was achieved by adding mPEG-SH in the CTAB solution, then, excess CTAB was removed by dialysis. PEG-modified gold nanoparticles showed a nearly neutral surface, and had little cytotoxicity in vitro. Following intravenous injection into mice, 54% of injected PEG-modified gold nanoparticles were found in blood at 0.5 h after intravenous injection, whereas most of gold was detected in the liver in the case of original gold nanorods stabilized with CTAB.
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U2 - 10.1016/j.jconrel.2006.06.017
DO - 10.1016/j.jconrel.2006.06.017
M3 - Article
C2 - 16876898
AN - SCOPUS:33748175984
SN - 0168-3659
VL - 114
SP - 343
EP - 347
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 3
ER -