TY - JOUR
T1 - Pediatric glioblastoma with oligodendroglioma component
T2 - Aggressive clinical phenotype with distinct molecular characteristics
AU - Mizoguchi, Masahiro
AU - Hata, Nobuhiro
AU - Suzuki, Satoshi O.
AU - Fujioka, Yutaka
AU - Murata, Hideki
AU - Amano, Toshiyuki
AU - Nakamizo, Akira
AU - Yoshimoto, Koji
AU - Iwaki, Toru
AU - Sasaki, Tomio
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013/12
Y1 - 2013/12
N2 - The 2007 World Health Organization classification defined a new variant of glioblastoma (GBM) containing oligodendroglioma foci as GBM with an oligodendroglioma component (GBMO), which shows a favorable clinical outcome compared with "classic" GBM. However, all of the reported cases of GBMO have been adult cases, with no previous reports of pediatric cases. In this report, we demonstrated molecular characteristics of a pediatric GBMO case, showing aggressive clinical behavior with 8-month overall survival. The case showed neither isocitrate dehydrogenase 1/2 genes (IDH1/2) mutation nor 1p/19q co-deletion, a hallmark of oligodendroglioal tumors. In addition, microsatellite instability, leading to the putative mechanism of temozolomide (TMZ) resistance, was frequently detected. Molecular genetic analysis may provide critical prognostic and therapeutic insights, especially for the pediatric glioma containing oligodendroglioma components.
AB - The 2007 World Health Organization classification defined a new variant of glioblastoma (GBM) containing oligodendroglioma foci as GBM with an oligodendroglioma component (GBMO), which shows a favorable clinical outcome compared with "classic" GBM. However, all of the reported cases of GBMO have been adult cases, with no previous reports of pediatric cases. In this report, we demonstrated molecular characteristics of a pediatric GBMO case, showing aggressive clinical behavior with 8-month overall survival. The case showed neither isocitrate dehydrogenase 1/2 genes (IDH1/2) mutation nor 1p/19q co-deletion, a hallmark of oligodendroglioal tumors. In addition, microsatellite instability, leading to the putative mechanism of temozolomide (TMZ) resistance, was frequently detected. Molecular genetic analysis may provide critical prognostic and therapeutic insights, especially for the pediatric glioma containing oligodendroglioma components.
UR - http://www.scopus.com/inward/record.url?scp=84897047054&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897047054&partnerID=8YFLogxK
U2 - 10.1111/neup.12029
DO - 10.1111/neup.12029
M3 - Article
C2 - 23530875
AN - SCOPUS:84897047054
SN - 0919-6544
VL - 33
SP - 652
EP - 657
JO - Neuropathology
JF - Neuropathology
IS - 6
ER -