PD-L1 expression on neoplastic or stromal cells is respectively a poor or good prognostic factor for adult T-cell leukemia/lymphoma

Hiroaki Miyoshi, Junichi Kiyasu, Takeharu Kato, Noriaki Yoshida, Joji Shimono, Shintaro Yokoyama, Hiroaki Taniguchi, Yuya Sasaki, Daisuke Kurita, Keisuke Kawamoto, Koji Kato, Yoshitaka Imaizumi, Masao Seto, Koichi Ohshima

    Research output: Contribution to journalArticlepeer-review

    97 Citations (Scopus)


    Programmed cell death ligand 1 (PD-L1) is expressed on both tumor and tumor-infiltrating nonmalignant cells in lymphoid malignancies. The programmed cell death 1 (PD-1)/PD-L1 pathway suppresses host antitumor responses, although little is known about the significance of PD-1/PD-L1 expression in the tumor microenvironment. To investigate the clinicopathological impact of PD-L1 expression in adult T-cell leukemia/lymphoma (ATLL), we performed PD-L1 immunostaining in 135 ATLL biopsy samples. We observed 2 main groups: 1 had clear PD-L1 expression in lymphoma cells (nPD-L1(1), 7.4% of patients), and the other showed minimal expression in lymphoma cells (nPD-L1(2), 92.6%). Within the nPD-L1(2) group, 2 subsets emerged: the first displayed abundant PD-L1 expression innonmalignant stromal cells of the tumor microenvironment(miPD-L1(1), 58.5%) and the second group did not express PD-L1 in any cell (PD-L1(2), 34.1%). nPD-L1(1) ATLL (median survival time [MST] 7.5 months, 95% CI [0.4-22.3]) had inferior overall survival (OS) compared with nPD-L1(2) ATLL (MST 14.5 months, 95% CI [10.1-20.0]) (P 5 .0085). Among nPD-L1(2) ATLL, miPD-L1(1) ATLL (MST 18.6 months, 95% CI [11.0-38.5]) showed superior OS compared with PD-L1(2) ATLL (MST 10.2 months, 95% CI [8.0-14.7]) (P 5 .0029). The expression of nPD-L1 and miPD-L1 maintained prognostic value for OS in multivariate analysis (P 5 .0322 and P 5 .0014, respectively). This is the first report describing the clinicopathological features and outcomes of PD-L1 expression in ATLL. More detailed studies will disclose clinical and biological significance of PD-L1 expression in ATLL.

    Original languageEnglish
    Pages (from-to)1374-1381
    Number of pages8
    Issue number10
    Publication statusPublished - Sept 8 2016

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Immunology
    • Hematology
    • Cell Biology


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