Patients with intractable epilepsy who achieved good seizure control after craniotomy instead of vagal nerve stimulation

Takato Morioka, Takashi Shimogawa, Tetsuro Sayama, Kimiaki Hashiguchi, Nobuya Murakami, Hiroshi Shigeto, Satoshi O. Suzuki, Ayumi Sakata, Kosuke Makihara, Koji Iihara

Research output: Contribution to journalArticlepeer-review


Vagal nerve stimulation (VNS) is an effective adjunctive therapy for medically intractable epilepsy. However, VNS is a palliative therapy, and craniotomy should preferably be performed when complete seizure remission can be expected after craniotomy. We report here three patients who were referred for VNS therapy, but underwent craniotomy instead of VNS based on the results of a comprehensive preoperative evaluation, and achieved good seizure control. Case 1 was a 48-year-old woman with left temporal lobe epilepsy and amygdalar enlargement. Even though no left hippocampal sclerosis was observed on magnetic resonance imaging, she underwent left anterior temporal lobectomy and hippocampectomy. Case 2 was a 36-year-old woman with multiple bilateral subependymal nodular heterotopias, who underwent resection of the left medial temporal lobe including subependymal nodular heterotopias adjacent to the left inferior horn. Case 3 was a 25-year-old man with posttraumatic epilepsy. As the right hemisphere was most affected, multiple subpial transections were performed on the left frontal convexity. These three patients were referred to us for VNS therapy because there was a dissociation between the interictal electroencephalogram and magnetic resonance imaging findings, or because they had multiple or extensive epileptogenic lesions. Comprehensive preoperative evaluation including ictal electroencephalography can help to identify patients who are suitable candidates for craniotomy.

Original languageEnglish
Pages (from-to)1137-1146
Number of pages10
JournalNeurological Surgery
Issue number12
Publication statusPublished - Dec 1 2014

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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