Palladium-catalyzed nucleophilic benzylic substitutions of benzylic esters

Ryoichi Kuwano, Yutaka Kondo, Yosuke Matsuyama

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145 Citations (Scopus)


A palladium complex generated in situ from [Pd(η3-C3H5)(cod)]BF4 and DPPF is a good catalyst for benzylic alkylation of benzyl methyl carbonate with the carbanion of dimethyl malonates. The catalytic reaction is applicable to a wide range of the benzylations of benzylic esters with malonates. The catalytic activity was heavily affected by the bite angle of the bidentate phosphine ligand on palladium. DPEphos ligand is superior to DPPF in the case of palladium-catalyzed benzylic amination of benzylic esters.

Original languageEnglish
Pages (from-to)12104-12105
Number of pages2
JournalJournal of the American Chemical Society
Issue number40
Publication statusPublished - Oct 8 2003

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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