Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer

Y. Takahashi; G. Sawada; J. Kurashige; R. Uchi; T. Matsumura; H. Ueo; Y. Takano; S. Akiyoshi; H. Eguchi; T. Sudo; K. Sugimachi; Y. Doki; M. Mori; K. Mimori

doi:10.1038/bjc.2013.339

Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer

Y. Takahashi
, G. Sawada
, J. Kurashige
, R. Uchi
, T. Matsumura
, H. Ueo
, Y. Takano
, S. Akiyoshi
, H. Eguchi
, T. Sudo
, K. Sugimachi
, Y. Doki
, M. Mori
, K. Mimori

Surgery

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Background:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.Methods:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.Results:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.Conclusion:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.

Original language	English
Pages (from-to)	307-311
Number of pages	5
Journal	British journal of cancer
Volume	109
Issue number	2
DOIs	https://doi.org/10.1038/bjc.2013.339
Publication status	Published - Jul 23 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1038/bjc.2013.339

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Takahashi, Y., Sawada, G., Kurashige, J., Uchi, R., Matsumura, T., Ueo, H., Takano, Y., Akiyoshi, S., Eguchi, H., Sudo, T., Sugimachi, K., Doki, Y., Mori, M., & Mimori, K. (2013). Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer. British journal of cancer, 109(2), 307-311. https://doi.org/10.1038/bjc.2013.339

Takahashi, Y, Sawada, G, Kurashige, J, Uchi, R, Matsumura, T, Ueo, H, Takano, Y, Akiyoshi, S, Eguchi, H, Sudo, T, Sugimachi, K, Doki, Y, Mori, M & Mimori, K 2013, 'Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer', British journal of cancer, vol. 109, no. 2, pp. 307-311. https://doi.org/10.1038/bjc.2013.339

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title = "Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer",

abstract = "Background:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.Methods:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.Results:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.Conclusion:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.",

keywords = "EMT, PRRX1, colorectal cancer, epithelial-to-mesenchymal transition, metastasis",

author = "Y. Takahashi and G. Sawada and J. Kurashige and R. Uchi and T. Matsumura and H. Ueo and Y. Takano and S. Akiyoshi and H. Eguchi and T. Sudo and K. Sugimachi and Y. Doki and M. Mori and K. Mimori",

note = "Funding Information: This work was supported in part by the following grants and foundations: CREST, Japan Science and Technology Agency (JST) and the Funding Program for Next Generation World-Leading Researchers (LS094). We also thank T Shimooka, M Kasagi, T Kawano, and S Kono for their technical assistance and H Miyoshi (RIKEN BioResource Center) for providing lentivirus vector plasmid DNA.",

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T1 - Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer

AU - Takahashi, Y.

AU - Sawada, G.

AU - Kurashige, J.

AU - Uchi, R.

AU - Matsumura, T.

AU - Ueo, H.

AU - Takano, Y.

AU - Akiyoshi, S.

AU - Eguchi, H.

AU - Sudo, T.

AU - Sugimachi, K.

AU - Doki, Y.

AU - Mori, M.

AU - Mimori, K.

N1 - Funding Information: This work was supported in part by the following grants and foundations: CREST, Japan Science and Technology Agency (JST) and the Funding Program for Next Generation World-Leading Researchers (LS094). We also thank T Shimooka, M Kasagi, T Kawano, and S Kono for their technical assistance and H Miyoshi (RIKEN BioResource Center) for providing lentivirus vector plasmid DNA.

PY - 2013/7/23

Y1 - 2013/7/23

N2 - Background:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.Methods:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.Results:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.Conclusion:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.

AB - Background:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.Methods:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.Results:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.Conclusion:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.

KW - EMT

KW - PRRX1

KW - colorectal cancer

KW - epithelial-to-mesenchymal transition

KW - metastasis

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Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer

Abstract

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