TY - JOUR
T1 - Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer
AU - Takahashi, Y.
AU - Sawada, G.
AU - Kurashige, J.
AU - Uchi, R.
AU - Matsumura, T.
AU - Ueo, H.
AU - Takano, Y.
AU - Akiyoshi, S.
AU - Eguchi, H.
AU - Sudo, T.
AU - Sugimachi, K.
AU - Doki, Y.
AU - Mori, M.
AU - Mimori, K.
N1 - Funding Information:
This work was supported in part by the following grants and foundations: CREST, Japan Science and Technology Agency (JST) and the Funding Program for Next Generation World-Leading Researchers (LS094). We also thank T Shimooka, M Kasagi, T Kawano, and S Kono for their technical assistance and H Miyoshi (RIKEN BioResource Center) for providing lentivirus vector plasmid DNA.
PY - 2013/7/23
Y1 - 2013/7/23
N2 - Background:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.Methods:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.Results:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.Conclusion:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.
AB - Background:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.Methods:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.Results:PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.Conclusion:PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.
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U2 - 10.1038/bjc.2013.339
DO - 10.1038/bjc.2013.339
M3 - Article
C2 - 23807160
AN - SCOPUS:84881107710
SN - 0007-0920
VL - 109
SP - 307
EP - 311
JO - British journal of cancer
JF - British journal of cancer
IS - 2
ER -
