Paclitaxel-induced peripheral neuropathy in male rats attenuated by calmangafodipir, a superoxide dismutase mimetic

Takehiro Kawashiri, Kohei Mori, Haruna Ishida, Mami Ueda, Kozo Yao, Fumiko Nagahama, Keisuke Mine, Yusuke Mori, Yusuke Koura, Shunsuke Fujita, Takao Shimazoe, Daisuke Kobayashi

Research output: Contribution to journalArticlepeer-review

Abstract

Paclitaxel induces peripheral neuropathy, which is considered a dose-limiting factor. However, appropriate prophylactic agents are currently unavailable. We investigated the prophylactic effects of calmangafodipir, a superoxide dismutase mimetic, on paclitaxel-induced peripheral neuropathy using a male rat model. Repeated administration of paclitaxel (6 mg/kg, intraperitoneal, once weekly for 4 weeks) resulted in mechanical allodynia in the von Frey test and axonal degeneration in the sciatic nerve. Conversely, calmangafodipir (1–10 mg/kg, intravenous, thrice weekly for 4 weeks) prevented mechanical allodynia and axonal degeneration induced by paclitaxel. These results suggest that calmangafodipir may inhibit paclitaxel-induced peripheral neuropathy.

Original languageEnglish
Pages (from-to)8-11
Number of pages4
JournalJournal of Pharmacological Sciences
Volume157
Issue number1
DOIs
Publication statusPublished - Jan 2025

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Fingerprint

Dive into the research topics of 'Paclitaxel-induced peripheral neuropathy in male rats attenuated by calmangafodipir, a superoxide dismutase mimetic'. Together they form a unique fingerprint.

Cite this