Oxytocin levels and sex differences in autism spectrum disorder with severe intellectual disabilities

Chie Aita, Yoshito Mizoguchi, Miwako Yamamoto, Yasuhisa SeguchI, Chiho Yatsuga, Taisuke Nishimura, Yoshiki Sugimoto, Daiki Takahashi, Reiko Nishihara, Takefumi Ueno, Masahiro Nakayama, Toshihide Kuroki, Hiromi Nabeta, Yoshiomi Imamura, Akira Monji

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


There were few reports of oxytocin (OXT) concentrations of autism spectrum disorder (ASD) patients with severe intellectual disabilities. We measured serum OXT concentrations in 79 hospitalized patients with severe intellectual disabilities (16–60 years old, 50 males and 29 females, 54 ASD patients) and investigated the associations between serum OXT concentration, symptom scores, sex differences, and autism spectrum disorder. There were no significant effects of diagnosis, severity of intellectual disabilities, and total score of the Japanese version of the Aberrant Behavior Checklist (ABC-J), the Childhood Autism Rating Scale-Tokyo Version (CARS-TV), and the Japanese version of the Repetitive Behavior Scale-Revised (RBS-R). However, there were sex differences in the correlations between OXT concentrations and subscale scores in the ASD group. The male ASD group (n = 39) showed negative correlations between RBS-R Self-injurious and Sameness subscale scores and serum OXT concentrations. In the female ASD group(n = 15), CARS-TV Nonverbal communication subscale scores and RBS-R Compulsive subscale scores were seen to positively correlate with serum OXT concentrations. These findings suggest that OXT functions differ in males and females with severe intellectual disabilities and that OXT partly affects autism and related to some of the repetitive behaviors and nonverbal communication, in ASD patients with severe intellectual disabilities.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalPsychiatry research
Publication statusPublished - Mar 2019

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry


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