Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water

Makoto Takenaka, Mitsuhiro Kikkawa, Takahiro Matsumoto, Takeshi Yatabe, Tatsuya Ando, Ki Seok Yoon, Seiji Ogo

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O2 and in water.

    Original languageEnglish
    Pages (from-to)3180-3184
    Number of pages5
    JournalChemistry - An Asian Journal
    Volume13
    Issue number21
    DOIs
    Publication statusPublished - Nov 2 2018

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water'. Together they form a unique fingerprint.

    Cite this