TY - JOUR
T1 - Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve
AU - Tsutsumi, Kuniaki
AU - Yamashita, Yuji
AU - Ushio, Soichiro
AU - Kawashiri, Takehiro
AU - Kaname, Takanori
AU - Fujita, Shunsuke
AU - Oishi, Ryozo
AU - Egashira, Nobuaki
N1 - Funding Information:
Part of this study was supported by research funding from the Nakatomi Foundation (Japan) and by JSPS KAKENHI Grant Numbers 22590242 , 25460335 , 25870496 . We appreciate the technical support provided by the Research Support Center, Graduate School of Medical Sciences, Kyushu University.
PY - 2014
Y1 - 2014
N2 - Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.
AB - Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.
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U2 - 10.1016/j.neures.2014.02.004
DO - 10.1016/j.neures.2014.02.004
M3 - Article
C2 - 24530887
AN - SCOPUS:84898814744
SN - 0168-0102
VL - 80
SP - 86
EP - 90
JO - Neuroscience Research
JF - Neuroscience Research
IS - 1
ER -