TY - JOUR
T1 - Overweight causes left ventricular diastolic asynchrony and diastolic dysfunction
T2 - A study based on speckle tracking echocardiography in healthy subjects
AU - Nakabachi, Masahiro
AU - Mikami, Taisei
AU - Okada, Kazunori
AU - Onozuka, Hisao
AU - Kaga, Sanae
AU - Inoue, Mamiko
AU - Yokoyama, Shinobu
AU - Nishida, Mutsumi
AU - Shimizu, Chikara
AU - Matsuno, Kazuhiko
AU - Iwano, Hiroyuki
AU - Yamada, Satoshi
AU - Tsutsui, Hiroyuki
N1 - Funding Information:
Acknowledgments This study was partly supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan, no. 19500412 (Taisei Mikami).
PY - 2012/9
Y1 - 2012/9
N2 - Background: Left ventricular (LV) diastolic dysfunction is often observed in healthy subjects and can be a cause of heart failure with preserved ejection fraction (EF). We aimed to investigate the role of LV diastolic asynchrony as a cause of diastolic dysfunction in healthy subjects. Methods: In 40 healthy subjects, two-dimensional speckle tracking imaging (2DSTI) was performed to measure the peak early diastolic longitudinal strain rates (Esr) of the apical, mid-ventricular, and basal segments of the septum and posterior wall. A mean value of the Esr of the 6 segments (mEsr) was calculated. The time from aortic valve closure to the Esr was measured for each segment, and the standard deviation (SDTEsr) was calculated. The peak global early diastolic strain rate (gEsr) was measured with a region of interest (ROI) on the whole LV myocardium. LV flow propagation velocity (FPV) was measured using conventional Doppler techniques. Results: SDTEsr was not correlated with age, but was significantly correlated with body mass index (BMI) (r = 0.41, p < 0.01). Although no significant correlation was observed between mEsr and FPV, gEsr and SDTEsr significantly correlated with FPV (r = 0.41, p < 0.01; r = -0.54, p < 0.001). As a result of the multiple regression analysis, SDTEsr was the single determinant of FPV. Conclusions: Diastolic asynchrony, associated with overweight but not with aging, may contribute to diastolic dysfunction in healthy subjects.
AB - Background: Left ventricular (LV) diastolic dysfunction is often observed in healthy subjects and can be a cause of heart failure with preserved ejection fraction (EF). We aimed to investigate the role of LV diastolic asynchrony as a cause of diastolic dysfunction in healthy subjects. Methods: In 40 healthy subjects, two-dimensional speckle tracking imaging (2DSTI) was performed to measure the peak early diastolic longitudinal strain rates (Esr) of the apical, mid-ventricular, and basal segments of the septum and posterior wall. A mean value of the Esr of the 6 segments (mEsr) was calculated. The time from aortic valve closure to the Esr was measured for each segment, and the standard deviation (SDTEsr) was calculated. The peak global early diastolic strain rate (gEsr) was measured with a region of interest (ROI) on the whole LV myocardium. LV flow propagation velocity (FPV) was measured using conventional Doppler techniques. Results: SDTEsr was not correlated with age, but was significantly correlated with body mass index (BMI) (r = 0.41, p < 0.01). Although no significant correlation was observed between mEsr and FPV, gEsr and SDTEsr significantly correlated with FPV (r = 0.41, p < 0.01; r = -0.54, p < 0.001). As a result of the multiple regression analysis, SDTEsr was the single determinant of FPV. Conclusions: Diastolic asynchrony, associated with overweight but not with aging, may contribute to diastolic dysfunction in healthy subjects.
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U2 - 10.1007/s12574-012-0133-1
DO - 10.1007/s12574-012-0133-1
M3 - Article
AN - SCOPUS:84866536113
SN - 1349-0222
VL - 10
SP - 83
EP - 89
JO - Journal of Echocardiography
JF - Journal of Echocardiography
IS - 3
ER -