Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

Zuoqing Dong; Shaohua Liu; Chengjun Zhou; Tomoki sumida; Hiroyuki Hamakawa; Zhenggang Chen; Pei Liu; Fengcai Wei

doi:10.1016/j.oraloncology.2009.11.005

Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

Zuoqing Dong, Shaohua Liu, Chengjun Zhou, Tomoki sumida, Hiroyuki Hamakawa, Zhenggang Chen, Pei Liu, Fengcai Wei

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p = 0.013), lymph node metastasis (p = 0.001), tumor stage (p = 0.031) and tumor recurrence (p = 0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r = 0.223, p = 0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.

Original language	English
Pages (from-to)	154-157
Number of pages	4
Journal	Oral Oncology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.oraloncology.2009.11.005
Publication status	Published - Mar 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oral Surgery
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.oraloncology.2009.11.005

Cite this

@article{c0e8deaf6c3b43faa5d99b2a876be185,

title = "Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma",

abstract = "We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p = 0.013), lymph node metastasis (p = 0.001), tumor stage (p = 0.031) and tumor recurrence (p = 0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r = 0.223, p = 0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.",

author = "Zuoqing Dong and Shaohua Liu and Chengjun Zhou and Tomoki sumida and Hiroyuki Hamakawa and Zhenggang Chen and Pei Liu and Fengcai Wei",

note = "Funding Information: This work was supported the National Natural Science Foundation of China (No. 30672339 ). ",

year = "2010",

month = mar,

doi = "10.1016/j.oraloncology.2009.11.005",

language = "English",

volume = "46",

pages = "154--157",

journal = "Oral Oncology",

issn = "1368-8375",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

AU - Dong, Zuoqing

AU - Liu, Shaohua

AU - Zhou, Chengjun

AU - sumida, Tomoki

AU - Hamakawa, Hiroyuki

AU - Chen, Zhenggang

AU - Liu, Pei

AU - Wei, Fengcai

N1 - Funding Information: This work was supported the National Natural Science Foundation of China (No. 30672339 ).

PY - 2010/3

Y1 - 2010/3

N2 - We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p = 0.013), lymph node metastasis (p = 0.001), tumor stage (p = 0.031) and tumor recurrence (p = 0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r = 0.223, p = 0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.

AB - We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p = 0.013), lymph node metastasis (p = 0.001), tumor stage (p = 0.031) and tumor recurrence (p = 0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r = 0.223, p = 0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.

UR - http://www.scopus.com/inward/record.url?scp=76749102880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76749102880&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2009.11.005

DO - 10.1016/j.oraloncology.2009.11.005

M3 - Article

C2 - 20056476

AN - SCOPUS:76749102880

SN - 1368-8375

VL - 46

SP - 154

EP - 157

JO - Oral Oncology

JF - Oral Oncology

IS - 3

ER -

Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this