Overexpression of bcl-2 protein inhibits terminal differentiation of oral keratinocytes in vitro

Hidemitsu Harada; Takeshi Mitsuyasu; Yuji Seta; Yuka Maruoka; Kuniaki Toyoshima; Shigeru Yasumoto

doi:10.1111/j.1600-0714.1998.tb02084.x

Overexpression of bcl-2 protein inhibits terminal differentiation of oral keratinocytes in vitro

Hidemitsu Harada, Takeshi Mitsuyasu, Yuji Seta, Yuka Maruoka, Kuniaki Toyoshima, Shigeru Yasumoto

Oral Surgery

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The bcl-2 proto-oncogene is a known inhibitor of apoptosis; in normal human stratified squamous epithelium, its expression is restricted to the basal cell layer. To investigate the functional role of bcl-2 protein in the process of differentiation of oral keratinocytes, bcl-2 expression vector was transfected into SCC-25 cells, which normally undergo squamous cell differentiation in vitro while expressing specific differentiation markers, e.g., keratin 10/11 and involucrin. In bcl-2 transfected SCC-25 cells, the expression of these differentiation markers was markedly suppressed. The bcl-2 proto-oncogene may play a critical role in opposing the commitment to terminal differentiation and apoptosis of oral keratinocytes.

Original language	English
Pages (from-to)	11-17
Number of pages	7
Journal	Journal of Oral Pathology and Medicine
Volume	27
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0714.1998.tb02084.x
Publication status	Published - Jan 1998

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Oral Surgery
Otorhinolaryngology
Cancer Research
Periodontics

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0714.1998.tb02084.x

Cite this

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AU - Toyoshima, Kuniaki

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Overexpression of bcl-2 protein inhibits terminal differentiation of oral keratinocytes in vitro

Abstract

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