Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

Kenneth E. Bernstein; Zakir Khan; Jorge F. Giani; Tuantuan Zhao; Masahiro Eriguchi; Ellen A. Bernstein; Romer A. Gonzalez-Villalobos; Xiao Z. Shen

doi:10.12688/f1000research.7508.1

Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

Kenneth E. Bernstein, Zakir Khan, Jorge F. Giani, Tuantuan Zhao, Masahiro Eriguchi, Ellen A. Bernstein, Romer A. Gonzalez-Villalobos, Xiao Z. Shen

Research output: Contribution to journal › Review article › peer-review

7 Citations (Scopus)

Abstract

Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

Original language	English
Article number	7508.1
Journal	F1000Research
Volume	5
DOIs	https://doi.org/10.12688/f1000research.7508.1
Publication status	Published - 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response",

abstract = "Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.",

author = "Bernstein, {Kenneth E.} and Zakir Khan and Giani, {Jorge F.} and Tuantuan Zhao and Masahiro Eriguchi and Bernstein, {Ellen A.} and Gonzalez-Villalobos, {Romer A.} and Shen, {Xiao Z.}",

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year = "2016",

doi = "10.12688/f1000research.7508.1",

language = "English",

volume = "5",

journal = "F1000Research",

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T1 - Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

AU - Bernstein, Kenneth E.

AU - Khan, Zakir

AU - Giani, Jorge F.

AU - Zhao, Tuantuan

AU - Eriguchi, Masahiro

AU - Bernstein, Ellen A.

AU - Gonzalez-Villalobos, Romer A.

AU - Shen, Xiao Z.

PY - 2016

Y1 - 2016

N2 - Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

AB - Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

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JO - F1000Research

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Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

Abstract

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