Over-expression of p53 protein in esophageal squamous cell carcinoma of women

Tadahiro Nozoe, Yoshihiko Maehara

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background/Aims: Most physicians naturally accept the etiological aspect that the incidence of esophageal squamous cell carcinoma (ESCC) is excessively more frequent in men than that in women. However, a definitely scientific confirmation to explain it has not been found. In the current study, we investigated the relationship between gender and p53 over-expression, which might resolve the difference between the genders in the mechanism for carcinogenesis in ESCC. Methodology: Immunohistochemical expression of p53 was examined for 134 ESCCs, and the correlation of the gender with the clinicopathologic features and over-expression of p53 was compared. Results: The proportion of p53 over-expression in women was 23.8% (5 out of 21) and this incidence proportion was significantly lower than that in men (48.7%, 55 out of 113; p=0.031). Conclusions: This biological modulation might be correlated with the lower incidence of ESCC in women.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
Issue number67
Publication statusPublished - Jan 2006

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


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