Orthopedic management of skeletal metastases

Nokitaka Setsu, Eisuke Kobayashi, Akira Kawai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Recent advances in drug therapy for metastatic bone diseases are changing the indications for surgical treatments. Bone-modifying agents, including bisphosphonates and denosumab, have reduced skeletal-related events. Meanwhile, novel anticancer drugs that have been developed, especially molecular-targeted drugs, can improve the prognoses of patients with bone metastases, thereby potentially increasing the number of patients who could receive benefits from surgeries for metastases. A multidisciplinary approach and the early involvement of surgeons are required for the application of adequate orthopedic treatments, including braces, rehabilitation, and surgeries for local tumor control, palliative fixation, and spinal decompression.

Original languageEnglish
Pages (from-to)1350-1354
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Issue number11
Publication statusPublished - Nov 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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