TY - JOUR
T1 - Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice
AU - Maeda, Naoyoshi
AU - Nakamura, Risa
AU - Hirose, Yoshitaka
AU - Murosaki, Shinji
AU - Yamamoto, Yoshihiro
AU - Kase, Tetsuo
AU - Yoshikai, Yasunobu
N1 - Funding Information:
This work was supported by Grant-in-Aid for Young Scientists (B) (to N. Maeda), and for Scientific Research on Priority Areas (to Y. Yoshikai) by Japan Society for the Promotion of Science (JSPS) and the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan; and by the Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases, which was launched as a project commissioned by the Ministry of Education, Culture, Sports, Science and Technology, Japan (to Y. Yoshikai).
PY - 2009/8
Y1 - 2009/8
N2 - We have previously reported that heat-killed Lactobacillus plantarum L-137 (HK-LP) stimulates macrophage/dendritic cells to produce T helper (Th) 1-related cytokines in vitro and in vivo in mice. We here examined the effect of oral administration of HK-LP on protection against influenza virus infection in mice. C57BL/6 mice were orally given HK-LP from day - 7 to 7 and intranasally infected with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) at 100 pfu on day 0. The survival time was significantly prolonged in mice treated with HK-LP than that in mice treated with PBS as controls. The viral titers in the lung were significantly lower in mice treated with HK-LP than controls at the early stage after influenza virus infection. An appreciable level of interferon (IFN)-β was detected in the serum of mice treated with HK-LP, while no IFN-β was detected in controls after influenza infection. Our results suggest that HK-LP, a potent IFN-β inducer, is useful for prevention against influenza infection.
AB - We have previously reported that heat-killed Lactobacillus plantarum L-137 (HK-LP) stimulates macrophage/dendritic cells to produce T helper (Th) 1-related cytokines in vitro and in vivo in mice. We here examined the effect of oral administration of HK-LP on protection against influenza virus infection in mice. C57BL/6 mice were orally given HK-LP from day - 7 to 7 and intranasally infected with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) at 100 pfu on day 0. The survival time was significantly prolonged in mice treated with HK-LP than that in mice treated with PBS as controls. The viral titers in the lung were significantly lower in mice treated with HK-LP than controls at the early stage after influenza virus infection. An appreciable level of interferon (IFN)-β was detected in the serum of mice treated with HK-LP, while no IFN-β was detected in controls after influenza infection. Our results suggest that HK-LP, a potent IFN-β inducer, is useful for prevention against influenza infection.
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U2 - 10.1016/j.intimp.2009.04.015
DO - 10.1016/j.intimp.2009.04.015
M3 - Article
C2 - 19410659
AN - SCOPUS:67649394141
SN - 1567-5769
VL - 9
SP - 1122
EP - 1125
JO - International Immunopharmacology
JF - International Immunopharmacology
IS - 9
ER -