One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging

Koichiro Hayashi; Kenji Ono; Hiromi Suzuki; Makoto Sawada; Makoto Moriya; Wataru Sakamoto; Toshinobu Yogo

doi:10.1021/cm100810g

One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging

Koichiro Hayashi, Kenji Ono, Hiromi Suzuki, Makoto Sawada, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

Cysteine-modified Fe₃O₄ nanoparticles (Cys-Fe ₃O₄ NPs) were synthesized by the one-pot biofunctionalization of allyl-functionalized Fe₃O₄ NPs (allyl-Fe₃O₄) with cysteine using the in situ hydrolysis-condensation of iron(III) allylacetylacetonate and the thiol-ene click reaction. The particle size of Fe₃O₄ in Cys-Fe ₃O₄ NPs measured by transmission electron microscopy and X-ray diffraction analysis was ∼8 nm. Cys-Fe₃O₄ NPs were soluble in water and had a hydrodynamic diameter of 22 nm and prolonged stability in water. They were superparamagnetic, which was confirmed by fitting the Langevin equation to the magnetization data, generated heat in an alternating current (AC) magnetic field, and had a specific absorption rate (SAR) of 156 W g^-1 at 230 kHz and 100 Oe. In addition, they exhibited a T₂-weighted magnetic resonance imaging (MRI) contrast-enhancing effect.

Original language	English
Pages (from-to)	3768-3772
Number of pages	5
Journal	Chemistry of Materials
Volume	22
Issue number	12
DOIs	https://doi.org/10.1021/cm100810g
Publication status	Published - Jun 22 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering
Materials Chemistry

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title = "One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging",

abstract = "Cysteine-modified Fe3O4 nanoparticles (Cys-Fe 3O4 NPs) were synthesized by the one-pot biofunctionalization of allyl-functionalized Fe3O4 NPs (allyl-Fe3O4) with cysteine using the in situ hydrolysis-condensation of iron(III) allylacetylacetonate and the thiol-ene click reaction. The particle size of Fe3O4 in Cys-Fe 3O4 NPs measured by transmission electron microscopy and X-ray diffraction analysis was ∼8 nm. Cys-Fe3O4 NPs were soluble in water and had a hydrodynamic diameter of 22 nm and prolonged stability in water. They were superparamagnetic, which was confirmed by fitting the Langevin equation to the magnetization data, generated heat in an alternating current (AC) magnetic field, and had a specific absorption rate (SAR) of 156 W g-1 at 230 kHz and 100 Oe. In addition, they exhibited a T2-weighted magnetic resonance imaging (MRI) contrast-enhancing effect.",

author = "Koichiro Hayashi and Kenji Ono and Hiromi Suzuki and Makoto Sawada and Makoto Moriya and Wataru Sakamoto and Toshinobu Yogo",

year = "2010",

month = jun,

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doi = "10.1021/cm100810g",

language = "English",

volume = "22",

pages = "3768--3772",

journal = "Chemistry of Materials",

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T1 - One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging

AU - Hayashi, Koichiro

AU - Ono, Kenji

AU - Suzuki, Hiromi

AU - Sawada, Makoto

AU - Moriya, Makoto

AU - Sakamoto, Wataru

AU - Yogo, Toshinobu

PY - 2010/6/22

Y1 - 2010/6/22

N2 - Cysteine-modified Fe3O4 nanoparticles (Cys-Fe 3O4 NPs) were synthesized by the one-pot biofunctionalization of allyl-functionalized Fe3O4 NPs (allyl-Fe3O4) with cysteine using the in situ hydrolysis-condensation of iron(III) allylacetylacetonate and the thiol-ene click reaction. The particle size of Fe3O4 in Cys-Fe 3O4 NPs measured by transmission electron microscopy and X-ray diffraction analysis was ∼8 nm. Cys-Fe3O4 NPs were soluble in water and had a hydrodynamic diameter of 22 nm and prolonged stability in water. They were superparamagnetic, which was confirmed by fitting the Langevin equation to the magnetization data, generated heat in an alternating current (AC) magnetic field, and had a specific absorption rate (SAR) of 156 W g-1 at 230 kHz and 100 Oe. In addition, they exhibited a T2-weighted magnetic resonance imaging (MRI) contrast-enhancing effect.

AB - Cysteine-modified Fe3O4 nanoparticles (Cys-Fe 3O4 NPs) were synthesized by the one-pot biofunctionalization of allyl-functionalized Fe3O4 NPs (allyl-Fe3O4) with cysteine using the in situ hydrolysis-condensation of iron(III) allylacetylacetonate and the thiol-ene click reaction. The particle size of Fe3O4 in Cys-Fe 3O4 NPs measured by transmission electron microscopy and X-ray diffraction analysis was ∼8 nm. Cys-Fe3O4 NPs were soluble in water and had a hydrodynamic diameter of 22 nm and prolonged stability in water. They were superparamagnetic, which was confirmed by fitting the Langevin equation to the magnetization data, generated heat in an alternating current (AC) magnetic field, and had a specific absorption rate (SAR) of 156 W g-1 at 230 kHz and 100 Oe. In addition, they exhibited a T2-weighted magnetic resonance imaging (MRI) contrast-enhancing effect.

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DO - 10.1021/cm100810g

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JO - Chemistry of Materials

JF - Chemistry of Materials

IS - 12

ER -

One-pot biofunctionalization of magnetic nanoparticles via thiol-ene click reaction for magnetic hyperthermia and magnetic resonance imaging

Abstract

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