On-chip cell manipulation by vibration-induced whirling flow

Takeshi Hayakawa; Shinya Sakuma; Fumihito Arai

doi:10.1109/MHS.2014.7006136

On-chip cell manipulation by vibration-induced whirling flow

Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We present a cell manipulation method by using vibration induced whirling flow. The local flow is induced just around a micropillar by applying circular vibration to the micropillar. By patterning a micropillar array on a chip and applying circular vibration to the chip, flow for cell transport can be generated along the array. As an application, we demonstrate a single cell extraction using the vibration-induced flow and single cell catcher made by thermo-responsive gel. Target cells are transported to the single cell catcher by vibration induced flow and caught by the single cell catcher. We tried 30 times single cell extraction, succeeded in 100% single cell catch and 60% extraction to external culture well.

Original language	English
Title of host publication	2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479966790
DOIs	https://doi.org/10.1109/MHS.2014.7006136
Publication status	Published - Jan 9 2015
Externally published	Yes
Event	2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014 - Nagoya, Japan Duration: Nov 10 2014 → Nov 12 2014

Publication series

Name	2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014

Other

Other	2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014
Country/Territory	Japan
City	Nagoya
Period	11/10/14 → 11/12/14

All Science Journal Classification (ASJC) codes

Electrical and Electronic Engineering
Mechanical Engineering

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10.1109/MHS.2014.7006136

Cite this

Hayakawa, T., Sakuma, S., & Arai, F. (2015). On-chip cell manipulation by vibration-induced whirling flow. In 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014 Article 7006136 (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2014.7006136

On-chip cell manipulation by vibration-induced whirling flow. / Hayakawa, Takeshi; Sakuma, Shinya; Arai, Fumihito.
2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014. Institute of Electrical and Electronics Engineers Inc., 2015. 7006136 (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Hayakawa, T, Sakuma, S & Arai, F 2015, On-chip cell manipulation by vibration-induced whirling flow. in 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014., 7006136, 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014, Institute of Electrical and Electronics Engineers Inc., 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014, Nagoya, Japan, 11/10/14. https://doi.org/10.1109/MHS.2014.7006136

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AB - We present a cell manipulation method by using vibration induced whirling flow. The local flow is induced just around a micropillar by applying circular vibration to the micropillar. By patterning a micropillar array on a chip and applying circular vibration to the chip, flow for cell transport can be generated along the array. As an application, we demonstrate a single cell extraction using the vibration-induced flow and single cell catcher made by thermo-responsive gel. Target cells are transported to the single cell catcher by vibration induced flow and caught by the single cell catcher. We tried 30 times single cell extraction, succeeded in 100% single cell catch and 60% extraction to external culture well.

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On-chip cell manipulation by vibration-induced whirling flow

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