Odorant receptor-mediated signaling in the mouse

Takeshi Imai, Hitoshi Sakano

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)


In the mouse olfactory system, there are ∼1000 types of odorant receptors (ORs), which perform multiple functions in olfactory sensory neurons (OSNs). In addition to detecting odors, the functional OR protein ensures the singular gene choice of the OR by negative-feedback regulation. ORs also direct the axonal projection of OSNs both globally and locally by modulating the transcriptional levels of axon-guidance and axon-sorting molecules. In these latter processes, the second messenger, cAMP, plays differential roles in the fasciculation and targeting of axons. In this review, we will discuss how ORs differentially regulate intracellular signals for distinct functions.

Original languageEnglish
Pages (from-to)251-260
Number of pages10
JournalCurrent Opinion in Neurobiology
Issue number3
Publication statusPublished - Jun 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


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