Nucleotide 2′,3′-cyclic monophosphokinase action of streptomyces nucleotide 3′-pyrophosphokinase

Jun Ichiro Mukai, Akinori Hirashima, Takeshi Mikuniya

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Streptomyces nucleotide 3′-pyrophosphokinase, formerly known to synthesize a variety of 3′-pyrophospho nucleotides by 5′-β,γ-pyrophosphoryl transfer from ATP, ATP 3′-pyrophosphate, and dATP, can also synthesize 2′,3′-cyclic monophospho nucleotides using diadenosine 5′,5′-poly (tri, tetra, and penta) phosphates as the phosphate donor. The examples are pA > p, ppA > p, pG > p, and CpG > p. Transient formation of an -N(3′)pp(5′)A structure via ADP transfer from the donor followed by AMP elimination is proposed as their synthetic mechanism.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalAgricultural and Biological Chemistry
Issue number1
Publication statusPublished - Jan 1991

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


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