Nuclease tolerant FRET probe based on DNA-quantum dot conjugation

Daisuke Onoshima, Noritada Kaji, Manabu Tokeshi, Yoshinobu Baba

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


We have developed a fluorescence resonance energy transfer (FRET) probe based on the conjugation of a quantum dot (QD) with dye (YOYO-3) intercalated DNA. The FRET-inducing electrostatic coupling of DNA and the QD made structural changes to the QD-DNA conjugates, which significantly prevented an enzymatic reaction between the DNA and a conventional restriction endonuclease (EcoRI). 2008

Original languageEnglish
Pages (from-to)181-183
Number of pages3
Journalanalytical sciences
Issue number2
Publication statusPublished - Feb 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry


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