TY - JOUR
T1 - Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh
AU - Yamasaki, Akio
AU - Kameda, Chizu
AU - Xu, Rui
AU - Tanaka, Haruo
AU - Tasaka, Takehiko
AU - Chikazawa, Nobuhito
AU - Suzuki, Hiroyuki
AU - Morisaki, Takashi
AU - Kubo, Makoto
AU - Onishi, Hideya
AU - Tanaka, Masao
AU - Katano, M.
N1 - Funding Information:
Acknowledgments This study was supported by General ScientiWc Research Grants (21390363) from the Ministry of Education, Culture, Sports and Technology of Japan. We thank Dr. K. Takeda for kindly providing us with the NF-B-dependent luciferase reporter, Dr. Aubie Shaw for kindly providing us with pSHH-GFP plasmids, and Dr. H. Yamamoto from Department of Anatomic Pathology, Kyushu University, for giving us an appropriate technical advice about immunohistochemistry. We also thank Kaori Nomiyama for the skillful technical assistance.
PY - 2010/5
Y1 - 2010/5
N2 - Recently, it was reported that Hh signaling is activated in tumor stromal cells but not in tumor cells themselves and that stromal cells may play a role in the proliferation of cancer cells. This suggests the possibility that stromal cells have an important role in the proliferation of tumor cells that may be mediated through Hh signaling. In this report, we present for the first time that inflammationstimulated monocytes produce Shh through activation of the NF-κB signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.
AB - Recently, it was reported that Hh signaling is activated in tumor stromal cells but not in tumor cells themselves and that stromal cells may play a role in the proliferation of cancer cells. This suggests the possibility that stromal cells have an important role in the proliferation of tumor cells that may be mediated through Hh signaling. In this report, we present for the first time that inflammationstimulated monocytes produce Shh through activation of the NF-κB signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.
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U2 - 10.1007/s00262-009-0783-7
DO - 10.1007/s00262-009-0783-7
M3 - Article
C2 - 19862523
AN - SCOPUS:77950505872
SN - 0340-7004
VL - 59
SP - 675
EP - 686
JO - Cancer Immunology, Immunotherapy
JF - Cancer Immunology, Immunotherapy
IS - 5
ER -
