Nuclear DNA content and nucleolar organizer regions in colorectal cancer

Yosuke Adachi, Akinori Kido, Masaki Mori, Tetsuya Matsushima, Reishi Shimono, Tetsuya Inoue, Keizo Sugimachi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The prognostic value of nuclear DNA content and argyrophilic nucleolar organizer regions (AgNOR) is still controversial in colorectal cancer. Sixty patients with colorectal cancer were studied by flow cytometric DNA analysis and AgNOR measurement, and their prognostic significance was tested. DNA index was closely linked to depth of invasion and lymph node metastasis, while AgNOR count did not correlate with such parameters. The survival curve was stongly influenced by depth of invasion, lymph node metastasis, and Dukes' stage but was not affected by DNA ploidy and AgNOR count. These results indicate that neither DNA ploidy nor AgNOR count correlates with survival of patients, although DNA ploidy is linked to progression of colorectal cancer.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalJournal of Surgical Oncology
Issue number3
Publication statusPublished - Jul 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology


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