Nuciferols A and B: Novel sesquineolignans from Cocos nucifera

M. Elsbaey, Bai Jie, Chiaki Tanaka, Hikaru Kato, Sachiko Tsukamoto, Kazuteru Usui, Go Hirai, Tomofumi Miyamoto

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Two novel epimers, named nuciferols A (1) and B (2), possessing a unique 6.9′, 9.6′, 7′.8″-cyclosesquineolignan skeleton, were isolated from the ethyl acetate fraction of the endocarp of Cocos nucifera. Their planar structure was elucidated by 1D-, 2D-NMR, HRESIMS and their absolute configuration was determined by ECD. Nuciferols A and B showed radical scavenging activity using DPPH assay, and only nuciferol B showed neuroprotective effects against t-BHP induced cell death in N2a cells.

Original languageEnglish
Article number150948
JournalTetrahedron Letters
Issue number33
Publication statusPublished - Aug 15 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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