TY - JOUR
T1 - Nuciferols A and B
T2 - Novel sesquineolignans from Cocos nucifera
AU - Elsbaey, M.
AU - Jie, Bai
AU - Tanaka, Chiaki
AU - Kato, Hikaru
AU - Tsukamoto, Sachiko
AU - Usui, Kazuteru
AU - Hirai, Go
AU - Miyamoto, Tomofumi
N1 - Funding Information:
The Egyptian Ministry of Higher Education and Scientific Research is acknowledged for the Post-doctoral fellowship support to Marwa Elsbaey.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Two novel epimers, named nuciferols A (1) and B (2), possessing a unique 6.9′, 9.6′, 7′.8″-cyclosesquineolignan skeleton, were isolated from the ethyl acetate fraction of the endocarp of Cocos nucifera. Their planar structure was elucidated by 1D-, 2D-NMR, HRESIMS and their absolute configuration was determined by ECD. Nuciferols A and B showed radical scavenging activity using DPPH assay, and only nuciferol B showed neuroprotective effects against t-BHP induced cell death in N2a cells.
AB - Two novel epimers, named nuciferols A (1) and B (2), possessing a unique 6.9′, 9.6′, 7′.8″-cyclosesquineolignan skeleton, were isolated from the ethyl acetate fraction of the endocarp of Cocos nucifera. Their planar structure was elucidated by 1D-, 2D-NMR, HRESIMS and their absolute configuration was determined by ECD. Nuciferols A and B showed radical scavenging activity using DPPH assay, and only nuciferol B showed neuroprotective effects against t-BHP induced cell death in N2a cells.
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U2 - 10.1016/j.tetlet.2019.150948
DO - 10.1016/j.tetlet.2019.150948
M3 - Article
AN - SCOPUS:85069704117
SN - 0040-4039
VL - 60
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 33
M1 - 150948
ER -