TY - JOUR
T1 - Nox4, a novel homologue of the phagocyte NADPH oxidase catalytic subunit gp91phox
AU - Shiose, Akira
AU - Kuribayashi, Futoshi
AU - Takeya, Ryu
AU - Sumimoto, Hideki
PY - 2002/11/1
Y1 - 2002/11/1
N2 - During phagocytosis, the NADPH oxidase in neutrophils produces superoxide, a precursor of microbicidal oxidants, thereby playing a crucial role in host defense. The phagocyte oxidase contains the two subunits p22phox and gp91phox, the latter of which contains binding sites for the heme, FAD, and NADPH, forming the complete electron-transporting apparatus. Recent studies have revealed that four nonphagocytic homologues of gp91phox exist, including Nox4, whose cDNA we have currently cloned. Here we describe the molecular nature of Nox4, in comparison with those of other members of the NAD(P)H oxidase family.
AB - During phagocytosis, the NADPH oxidase in neutrophils produces superoxide, a precursor of microbicidal oxidants, thereby playing a crucial role in host defense. The phagocyte oxidase contains the two subunits p22phox and gp91phox, the latter of which contains binding sites for the heme, FAD, and NADPH, forming the complete electron-transporting apparatus. Recent studies have revealed that four nonphagocytic homologues of gp91phox exist, including Nox4, whose cDNA we have currently cloned. Here we describe the molecular nature of Nox4, in comparison with those of other members of the NAD(P)H oxidase family.
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U2 - 10.1016/S0531-5131(02)00314-X
DO - 10.1016/S0531-5131(02)00314-X
M3 - Article
AN - SCOPUS:85023026252
SN - 0531-5131
VL - 1233
SP - 63
EP - 68
JO - International Congress Series
JF - International Congress Series
IS - C
ER -