Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese

Tetsuya Saito; Mari Egashira; Kazuma Kiyotani; Masaki Fujieda; Hiroshi Yamazaki; Chikako Kiyohara; Hideo Kunitoh; Tetsuya Kamataki

doi:10.2133/dmpk.18.218

Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese

Tetsuya Saito, Mari Egashira, Kazuma Kiyotani, Masaki Fujieda, Hiroshi Yamazaki, Chikako Kiyohara, Hideo Kunitoh, Tetsuya Kamataki

Social Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile⁴⁴⁸Asn, Arg⁴⁶⁴Cys, and Arg⁴⁷⁷Trp and Pro⁴⁹²Arg, respectively) were as follows: SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTC A ACCC ATCT-/TG AGTTCCT ACCT-3'. SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTG AG A AGGTG AT / AT ATCTTTGGC AT-3'. SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'. SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' - ATCCTGCTGC A A C /TGGGTGG A ATTC A-3'. SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' -TGG ACATG ACCCC /GC ATCT ATGGGCT-3'.

Original language	English
Pages (from-to)	218-221
Number of pages	4
Journal	Drug metabolism and pharmacokinetics
Volume	18
Issue number	3
DOIs	https://doi.org/10.2133/dmpk.18.218
Publication status	Published - Feb 1 2003

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science
Pharmacology (medical)

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@article{7c17d5d515704012997c6e625624e0e9,

title = "Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese",

abstract = "We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile448Asn, Arg464Cys, and Arg477Trp and Pro492Arg, respectively) were as follows: SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTC A ACCC ATCT-/TG AGTTCCT ACCT-3'. SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTG AG A AGGTG AT / AT ATCTTTGGC AT-3'. SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'. SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' - ATCCTGCTGC A A C /TGGGTGG A ATTC A-3'. SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' -TGG ACATG ACCCC /GC ATCT ATGGGCT-3'.",

author = "Tetsuya Saito and Mari Egashira and Kazuma Kiyotani and Masaki Fujieda and Hiroshi Yamazaki and Chikako Kiyohara and Hideo Kunitoh and Tetsuya Kamataki",

year = "2003",

month = feb,

day = "1",

doi = "10.2133/dmpk.18.218",

language = "English",

volume = "18",

pages = "218--221",

journal = "Drug metabolism and pharmacokinetics",

issn = "1347-4367",

publisher = "Japanese Society for the Study of Xenobiotics",

number = "3",

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TY - JOUR

T1 - Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese

AU - Saito, Tetsuya

AU - Egashira, Mari

AU - Kiyotani, Kazuma

AU - Fujieda, Masaki

AU - Yamazaki, Hiroshi

AU - Kiyohara, Chikako

AU - Kunitoh, Hideo

AU - Kamataki, Tetsuya

PY - 2003/2/1

Y1 - 2003/2/1

N2 - We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile448Asn, Arg464Cys, and Arg477Trp and Pro492Arg, respectively) were as follows: SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTC A ACCC ATCT-/TG AGTTCCT ACCT-3'. SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTG AG A AGGTG AT / AT ATCTTTGGC AT-3'. SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'. SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' - ATCCTGCTGC A A C /TGGGTGG A ATTC A-3'. SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' -TGG ACATG ACCCC /GC ATCT ATGGGCT-3'.

AB - We found five novel nonsynonymous polymorphisms of the human CYP1A1 gene from Japanese individuals. The five single nucleotide polymorphisms (SNP) in exon 7 (2346_2347 ins T, 2414T>A, 2461C>T, 2500C>T and 2546C>G causing premature stop codon, Ile448Asn, Arg464Cys, and Arg477Trp and Pro492Arg, respectively) were as follows: SNP, 030212Saito001; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTC A ACCC ATCT-/TG AGTTCCT ACCT-3'. SNP, 030212Saito002; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GTG AG A AGGTG AT / AT ATCTTTGGC AT-3'. SNP, 030212Saito003; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5'-GAGACCGTTGCCC/TGCTGGGAGGTCT-3'. SNP, 030212Saito004; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' - ATCCTGCTGC A A C /TGGGTGG A ATTC A-3'. SNP, 030212Saito005; GENE NAME, CYP1A1; ACCESSION NUMBER, ☒ LENGTH, 25 base; 5' -TGG ACATG ACCCC /GC ATCT ATGGGCT-3'.

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U2 - 10.2133/dmpk.18.218

DO - 10.2133/dmpk.18.218

M3 - Article

AN - SCOPUS:85009638381

SN - 1347-4367

VL - 18

SP - 218

EP - 221

JO - Drug metabolism and pharmacokinetics

JF - Drug metabolism and pharmacokinetics

IS - 3

ER -

Novel Nonsynonymous Polymorphisms of the CYP1AI Gene in Japanese

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