TY - JOUR
T1 - Novel Estrogen Receptor Inhibitory Mechanism for Halogen─containing Endocrine─ disrupting Chemicals Discovered by Computer Simulation
AU - Matsushima, Ayami
N1 - Publisher Copyright:
© 2023 Society of Synthetic Organic Chemistry. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Bisphenol A (BPA) is a component used in the manufacture of polycarbonate plastics and epoxy resins around the world; however, it is also well-known as one of the most notorious endocrine-disrupting chemicals. To avoid using BPA as an ingredient, various BPA derivatives and related compounds have been synthesized and the use of these for making polymers has grown significantly; however, the safety of these BPA derivatives, also known as next-generation bisphenols, has not been fully evaluated. We hypothesized that the bisphenol moiety is a privileged structure for binding to nuclear receptors. Here, we summarize the binding ability of next-generation bisphenols to estrogen receptors and show that halogen-containing bisphenols act as coactivator binding inhibitors for estrogen receptor β.
AB - Bisphenol A (BPA) is a component used in the manufacture of polycarbonate plastics and epoxy resins around the world; however, it is also well-known as one of the most notorious endocrine-disrupting chemicals. To avoid using BPA as an ingredient, various BPA derivatives and related compounds have been synthesized and the use of these for making polymers has grown significantly; however, the safety of these BPA derivatives, also known as next-generation bisphenols, has not been fully evaluated. We hypothesized that the bisphenol moiety is a privileged structure for binding to nuclear receptors. Here, we summarize the binding ability of next-generation bisphenols to estrogen receptors and show that halogen-containing bisphenols act as coactivator binding inhibitors for estrogen receptor β.
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U2 - 10.5059/yukigoseikyokaishi.81.1096
DO - 10.5059/yukigoseikyokaishi.81.1096
M3 - Article
AN - SCOPUS:85179012263
SN - 0037-9980
VL - 81
SP - 1103
EP - 1109
JO - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
JF - Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
IS - 11
ER -