Novel acylated triterpene glycosides from Muraltia heisteria

Mohamed Elbandy; Tomofumi Miyamoto; Bruno Chauffert; Clément Delaude; Marie Aleth Lacaille-Dubois

doi:10.1021/np010381+

Novel acylated triterpene glycosides from Muraltia heisteria

Mohamed Elbandy, Tomofumi Miyamoto, Bruno Chauffert, Clément Delaude, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Four new acylated triterpene glycosides (1-4) have been isolated as two inseparable mixtures of the trans- and cis-3,4,5-trimethoxycinnamoyl derivatives (1,2 and 3,4) from the roots of Muraltia heisteria. The structures of these compounds were elucidated by various 1D and 2D NMR techniques, including ¹H and ¹³C, COSY, NOESY, HSQC, TOCSY, and HMBC experiments and FABMS: Compounds 3 and 4 were shown to be cytotoxic in a human colon cancer cell line but did not show any ability to potentiate in vitro cisplatin cytotoxicity.

Original language	English
Pages (from-to)	193-197
Number of pages	5
Journal	Journal of Natural Products
Volume	65
Issue number	2
DOIs	https://doi.org/10.1021/np010381+
Publication status	Published - 2002

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np010381+

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abstract = "Four new acylated triterpene glycosides (1-4) have been isolated as two inseparable mixtures of the trans- and cis-3,4,5-trimethoxycinnamoyl derivatives (1,2 and 3,4) from the roots of Muraltia heisteria. The structures of these compounds were elucidated by various 1D and 2D NMR techniques, including 1H and 13C, COSY, NOESY, HSQC, TOCSY, and HMBC experiments and FABMS: Compounds 3 and 4 were shown to be cytotoxic in a human colon cancer cell line but did not show any ability to potentiate in vitro cisplatin cytotoxicity.",

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AU - Elbandy, Mohamed

AU - Miyamoto, Tomofumi

AU - Chauffert, Bruno

AU - Delaude, Clément

AU - Lacaille-Dubois, Marie Aleth

PY - 2002

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AB - Four new acylated triterpene glycosides (1-4) have been isolated as two inseparable mixtures of the trans- and cis-3,4,5-trimethoxycinnamoyl derivatives (1,2 and 3,4) from the roots of Muraltia heisteria. The structures of these compounds were elucidated by various 1D and 2D NMR techniques, including 1H and 13C, COSY, NOESY, HSQC, TOCSY, and HMBC experiments and FABMS: Compounds 3 and 4 were shown to be cytotoxic in a human colon cancer cell line but did not show any ability to potentiate in vitro cisplatin cytotoxicity.

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Novel acylated triterpene glycosides from Muraltia heisteria

Abstract

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