TY - JOUR
T1 - Nonsegmental vitiligo update
AU - Furue, Masutaka
AU - Kadono, Takafumi
N1 - Publisher Copyright:
© 2016
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Nonsegmental vitiligo is an acquired leukoderma characterized by the destruction of melanocytes. Autoimmunity is the most widely accepted hypothesis to explain the pathogenesis of nonsegmental vitiligo. Increased oxidative stress and decreased expression of E-cadherin may facilitate the loss of melanocytes. Because vitiligo preferentially affects cosmetically sensitive regions such as the face, hands, and genital area, it imposes significant psychological and social burdens. In this review, we discuss recent topics in the epidemiology, pathogenesis, genetic background, and therapeutic advances of nonsegmental vitiligo.
AB - Nonsegmental vitiligo is an acquired leukoderma characterized by the destruction of melanocytes. Autoimmunity is the most widely accepted hypothesis to explain the pathogenesis of nonsegmental vitiligo. Increased oxidative stress and decreased expression of E-cadherin may facilitate the loss of melanocytes. Because vitiligo preferentially affects cosmetically sensitive regions such as the face, hands, and genital area, it imposes significant psychological and social burdens. In this review, we discuss recent topics in the epidemiology, pathogenesis, genetic background, and therapeutic advances of nonsegmental vitiligo.
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U2 - 10.1016/j.dsi.2016.07.001
DO - 10.1016/j.dsi.2016.07.001
M3 - Review article
AN - SCOPUS:84994493000
SN - 1027-8117
VL - 34
SP - 173
EP - 176
JO - Dermatologica Sinica
JF - Dermatologica Sinica
IS - 4
ER -