Nonmyeloablative stem cell transplantation with low-dose total body irradiation (200 cGy) for a 55-year-old woman with acute lymphoblastic leukemia

Y. Abe; K. Hara; I. Choi; M. Shiratsuchi; T. Matsushima; R. Minami; T. Kihara; J. Nishimura; S. Inaba; H. Nawata; K. Muta

Nonmyeloablative stem cell transplantation with low-dose total body irradiation (200 cGy) for a 55-year-old woman with acute lymphoblastic leukemia

Y. Abe, K. Hara, I. Choi, M. Shiratsuchi, T. Matsushima, R. Minami, T. Kihara, J. Nishimura, S. Inaba, H. Nawata, K. Muta

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Abstract

We describe a 55-year-old woman with acute lymphoblastic leukemia (ALL) in the first remission who underwent nonmyeloablative stem cell transplantation with conditioning consisting of low-dose total body irradiation and postgrafting cyclosporine and mycophenolate mofetil. Myelosuppression was mild, but on day 28 her bone marrow showed 8.8% lymphoblasts. We withdrew the cyclosporine, but the patient developed grade 2 acute GVHD and eosinophilia. The proportion of bone marrow lymphoblasts decreased transiently to 1.0% on day 40, but later increased again and the patient died on day 85. Application of this approach to patients with ALL needs to be examined on a large scale.

Original language	English
Pages (from-to)	1277-1280
Number of pages	4
Journal	[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume	41
Issue number	12
Publication status	Published - Dec 2000

All Science Journal Classification (ASJC) codes

Medicine(all)

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Abe, Y., Hara, K., Choi, I., Shiratsuchi, M., Matsushima, T., Minami, R., Kihara, T., Nishimura, J., Inaba, S., Nawata, H., & Muta, K. (2000). Nonmyeloablative stem cell transplantation with low-dose total body irradiation (200 cGy) for a 55-year-old woman with acute lymphoblastic leukemia. [Rinshō ketsueki] The Japanese journal of clinical hematology, 41(12), 1277-1280.

Abe, Y, Hara, K, Choi, I, Shiratsuchi, M, Matsushima, T, Minami, R, Kihara, T, Nishimura, J, Inaba, S, Nawata, H & Muta, K 2000, 'Nonmyeloablative stem cell transplantation with low-dose total body irradiation (200 cGy) for a 55-year-old woman with acute lymphoblastic leukemia', [Rinshō ketsueki] The Japanese journal of clinical hematology, vol. 41, no. 12, pp. 1277-1280.

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abstract = "We describe a 55-year-old woman with acute lymphoblastic leukemia (ALL) in the first remission who underwent nonmyeloablative stem cell transplantation with conditioning consisting of low-dose total body irradiation and postgrafting cyclosporine and mycophenolate mofetil. Myelosuppression was mild, but on day 28 her bone marrow showed 8.8% lymphoblasts. We withdrew the cyclosporine, but the patient developed grade 2 acute GVHD and eosinophilia. The proportion of bone marrow lymphoblasts decreased transiently to 1.0% on day 40, but later increased again and the patient died on day 85. Application of this approach to patients with ALL needs to be examined on a large scale.",

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AU - Abe, Y.

AU - Hara, K.

AU - Choi, I.

AU - Shiratsuchi, M.

AU - Matsushima, T.

AU - Minami, R.

AU - Kihara, T.

AU - Nishimura, J.

AU - Inaba, S.

AU - Nawata, H.

AU - Muta, K.

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N2 - We describe a 55-year-old woman with acute lymphoblastic leukemia (ALL) in the first remission who underwent nonmyeloablative stem cell transplantation with conditioning consisting of low-dose total body irradiation and postgrafting cyclosporine and mycophenolate mofetil. Myelosuppression was mild, but on day 28 her bone marrow showed 8.8% lymphoblasts. We withdrew the cyclosporine, but the patient developed grade 2 acute GVHD and eosinophilia. The proportion of bone marrow lymphoblasts decreased transiently to 1.0% on day 40, but later increased again and the patient died on day 85. Application of this approach to patients with ALL needs to be examined on a large scale.

AB - We describe a 55-year-old woman with acute lymphoblastic leukemia (ALL) in the first remission who underwent nonmyeloablative stem cell transplantation with conditioning consisting of low-dose total body irradiation and postgrafting cyclosporine and mycophenolate mofetil. Myelosuppression was mild, but on day 28 her bone marrow showed 8.8% lymphoblasts. We withdrew the cyclosporine, but the patient developed grade 2 acute GVHD and eosinophilia. The proportion of bone marrow lymphoblasts decreased transiently to 1.0% on day 40, but later increased again and the patient died on day 85. Application of this approach to patients with ALL needs to be examined on a large scale.

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Nonmyeloablative stem cell transplantation with low-dose total body irradiation (200 cGy) for a 55-year-old woman with acute lymphoblastic leukemia

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