Nonlinear multiscale circulation model reproducable linear end-systolic pressure-volume relationship

Takao Shimayoshi, Mitsuharu Mishima, Akira Amano, Tetsuya Matsuda

Research output: Contribution to journalArticlepeer-review


As a well-known property of the heart, many studies has reported that the left ventricular end-systolic pressure-volume relationship (ESPVR) is linear. However, the reason of the linearity is poorly understood. This article presents a multiscale circulation model to be a tool for theoretical analyses on the mechanism of the linearity of ESPVR. The model is composed of three sub-models; a detailed closed-loop lumped-parameter model for cardiovascular system, geometric left ventricle model, a comprehensive ventricular myocyte model. Although the present model integrates nonlinear sub-models, the model can successfully reproduce highly linear ESPVR without any arbitrary modifications.

Original languageEnglish
Pages (from-to)6778-6781
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Publication statusPublished - 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


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