TY - JOUR
T1 - Nonfamilial Prealbumin-Type Amyloid Polyneuropathy
AU - Ochiai, Jun
AU - Tobimatsu, Shozo
AU - Kobayashi, Takuro
AU - Kitamoto, Tetsuyuki
AU - Kitaguchi, Tetsuo
AU - Furuya, Hirokazu
AU - Goto, Ikuo
AU - Kuroiwa, Yoshigoro
PY - 1986/12
Y1 - 1986/12
N2 - A 53-year-old man with nonfamilial prealbumin-type amyloid polyneuropathy had severe motor, sensory, and autonomic polyneuropathy, beginning at age 48 years. These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal. Thus, the diagnosis of FAP was excluded. A possible diagnosis of systemic senile amyloidosis was also considered.
AB - A 53-year-old man with nonfamilial prealbumin-type amyloid polyneuropathy had severe motor, sensory, and autonomic polyneuropathy, beginning at age 48 years. These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal. Thus, the diagnosis of FAP was excluded. A possible diagnosis of systemic senile amyloidosis was also considered.
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U2 - 10.1001/archneur.1986.00520120070021
DO - 10.1001/archneur.1986.00520120070021
M3 - Article
C2 - 3022697
AN - SCOPUS:0023001870
SN - 0003-9942
VL - 43
SP - 1294
EP - 1295
JO - Archives of Neurology
JF - Archives of Neurology
IS - 12
ER -