@article{f927a1e25c0a4473b6cbbc5c954efa7d,
title = "Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo",
abstract = "Patterning of the mouse embryo along the anteroposterior axis during body plan development requires migration of the distal visceral endoderm (DVE) towards the future anterior side by a mechanism that has remained unknown. Here we show that Nodal signalling and the regionalization of its antagonists are required for normal migration of the DVE. Whereas Nodal signalling provides the driving force for DVE migration by stimulating the proliferation of visceral endoderm cells, the antagonists Lefty1 and Cerl determine the direction of migration by asymmetrically inhibiting Nodal activity on the future anterior side.",
author = "Masamichi Yamamoto and Yukio Saijoh and Altana Perea-Gomez and William Shawiot and Behringer, {Richard R.} and Ang, {Siew Lan} and Hiroshi Hamada and Chikara Meno",
note = "Funding Information: Acknowledgements We thank E. Robertson for NodallacZ mutant mice; R. Beddington for the Hex probe; V. Gallo for expression vectors for Cdk and dominant negative Cdk; and N. Mine and Y. Ohnishi for help in improving the lipofection procedure. We also thank S. Srinivas for exchanging unpublished data. This work was supported by grants from the Ministry of Education, Science, Sports, and Culture of Japan (to C.M. and H.H.), a grant from CREST (Core Research for Evolutional Science and Technology) of the Japan Science and Technology Corporation (to H.H.), a grant from the NIH (to R.R.B.), and a grant from the Association pour la Recherche sur le Cancer and by funds from the INSERM, the CNRS and the Hopital Universitaire de Strasbourg (to S.-L.A.). M.Y. is a recipient of a fellowship from the Japan Society for the Promotion of Science for Japanese Junior Scientists.",
year = "2004",
month = mar,
day = "25",
doi = "10.1038/nature02418",
language = "English",
volume = "428",
pages = "387--392",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6981",
}