TY - JOUR
T1 - Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with β-amyloid in rats
AU - Iwasaki, Katsunori
AU - Egashira, Nobuaki
AU - Takagaki, Yuki
AU - Yoshimitsu, Yoshitaka
AU - Hatip-Al-Khatib, Izzettin
AU - Mishima, Kenichi
AU - Fujiwara, Michihiro
PY - 2007/4/1
Y1 - 2007/4/1
N2 - In the present study, we examined the effects of nilvadipine and amlodipine, both dihydropyridine-derivative calcium antagonists, on the impairment of spatial memory induced by a combination of ischemia and β-amyloid (Aβ). Nilvadipine (3.2 mg/kg, i.p.) significantly prevented the impairment of spatial memory and neuronal apoptosis in this model. By contrast, amlodipine had no effect on this impairment of spatial memory. These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD).
AB - In the present study, we examined the effects of nilvadipine and amlodipine, both dihydropyridine-derivative calcium antagonists, on the impairment of spatial memory induced by a combination of ischemia and β-amyloid (Aβ). Nilvadipine (3.2 mg/kg, i.p.) significantly prevented the impairment of spatial memory and neuronal apoptosis in this model. By contrast, amlodipine had no effect on this impairment of spatial memory. These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD).
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U2 - 10.1248/bpb.30.698
DO - 10.1248/bpb.30.698
M3 - Article
C2 - 17409505
AN - SCOPUS:34147128293
SN - 0918-6158
VL - 30
SP - 698
EP - 701
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
IS - 4
ER -