NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes

Kazunori Nakayama, Hideya Onishi, Akiko Fujimura, Akira Imaizumi, Makoto Kawamoto, Yasuhiro Oyama, Shu Ichimiya, Satoko Koga, Yuichi Fujimoto, Kinichi Nakashima, Masafumi Nakamura

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4 Citations (Scopus)


We previously reported that protein tyrosine phosphatase non-receptor type 3 (PTPN3), which is upregulated in activated lymphocytes, acts as an immune checkpoint. However, the mechanism by which PTPN3 expression is enhanced in activated lymphocytes is unknown. In this study, we analyzed the mechanism of PTPN3 expression in activated lymphocytes with a view for developing a novel immune checkpoint inhibitor that suppresses PTPN3. Through the activation process, lymphocytes showed enhanced NFκB activation as well as increased PTPN3 expression. NFκB enhanced proliferation, migration, and cytotoxicity of lymphocytes. Furthermore, NFκB enhanced PTPN3 expression and tyrosine kinase activation. TGFβ reduced PTPN3 expression and NFκB activation in the cancer microenvironment, and suppressed the biological activity of lymphocytes. The results of this study are expected to provide significant implications for improving existing immunotherapy and developing novel immunotherapy.

Original languageEnglish
Article number104237
JournalCellular Immunology
Publication statusPublished - Dec 2020

All Science Journal Classification (ASJC) codes

  • Immunology


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