Newly Improved Simulated Body Fluid

Hiroaki Takadama; Masami Hashimoto; Mineo Mizuno; Kunio Ishikawa; Tadashi Kokubo

Newly Improved Simulated Body Fluid

Hiroaki Takadama, Masami Hashimoto, Mineo Mizuno, Kunio Ishikawa, Tadashi Kokubo

Oral Rehabilitation

Research output: Contribution to journal › Conference article › peer-review

10 Citations (Scopus)

Abstract

A newly improved simulated body fluid (n-SBF) was designed to have concentrations of ions equal to those of human blood plasma excepting that of HCO₃, the concentration of which is lower than the level of saturation with respect to calcite. The preparation process was modified and two different preparing processes such as powder dissolving and liquid mixing processes were attempted. The n-SBFs with nominal ion concentration can be prepared and its concentrations were unchanged over 4 weeks. The bioactive glasses showed almost same bioactivity in both n-SBFs and c-SBF. The n-SBFs is believed to produce apatite under quite similar condition to the body environment, thereby being useful for in vitro assessment of bioactivity of artificial material.

Original language	English
Pages (from-to)	115-118
Number of pages	4
Journal	Key Engineering Materials
Volume	254-256
Publication status	Published - Jan 1 2004
Event	The Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal Duration: Nov 6 2003 → Nov 9 2003

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Newly Improved Simulated Body Fluid",

abstract = "A newly improved simulated body fluid (n-SBF) was designed to have concentrations of ions equal to those of human blood plasma excepting that of HCO3, the concentration of which is lower than the level of saturation with respect to calcite. The preparation process was modified and two different preparing processes such as powder dissolving and liquid mixing processes were attempted. The n-SBFs with nominal ion concentration can be prepared and its concentrations were unchanged over 4 weeks. The bioactive glasses showed almost same bioactivity in both n-SBFs and c-SBF. The n-SBFs is believed to produce apatite under quite similar condition to the body environment, thereby being useful for in vitro assessment of bioactivity of artificial material.",

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note = "The Annual Meeting of the International Society for Ceramics in Medicine ; Conference date: 06-11-2003 Through 09-11-2003",

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TY - JOUR

T1 - Newly Improved Simulated Body Fluid

AU - Takadama, Hiroaki

AU - Hashimoto, Masami

AU - Mizuno, Mineo

AU - Ishikawa, Kunio

AU - Kokubo, Tadashi

PY - 2004/1/1

Y1 - 2004/1/1

N2 - A newly improved simulated body fluid (n-SBF) was designed to have concentrations of ions equal to those of human blood plasma excepting that of HCO3, the concentration of which is lower than the level of saturation with respect to calcite. The preparation process was modified and two different preparing processes such as powder dissolving and liquid mixing processes were attempted. The n-SBFs with nominal ion concentration can be prepared and its concentrations were unchanged over 4 weeks. The bioactive glasses showed almost same bioactivity in both n-SBFs and c-SBF. The n-SBFs is believed to produce apatite under quite similar condition to the body environment, thereby being useful for in vitro assessment of bioactivity of artificial material.

AB - A newly improved simulated body fluid (n-SBF) was designed to have concentrations of ions equal to those of human blood plasma excepting that of HCO3, the concentration of which is lower than the level of saturation with respect to calcite. The preparation process was modified and two different preparing processes such as powder dissolving and liquid mixing processes were attempted. The n-SBFs with nominal ion concentration can be prepared and its concentrations were unchanged over 4 weeks. The bioactive glasses showed almost same bioactivity in both n-SBFs and c-SBF. The n-SBFs is believed to produce apatite under quite similar condition to the body environment, thereby being useful for in vitro assessment of bioactivity of artificial material.

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M3 - Conference article

AN - SCOPUS:0346885610

SN - 1013-9826

VL - 254-256

SP - 115

EP - 118

JO - Key Engineering Materials

JF - Key Engineering Materials

T2 - The Annual Meeting of the International Society for Ceramics in Medicine

Y2 - 6 November 2003 through 9 November 2003

ER -

Newly Improved Simulated Body Fluid

Abstract

All Science Journal Classification (ASJC) codes

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