Newly Improved Simulated Body Fluid

Hiroaki Takadama, Masami Hashimoto, Mineo Mizuno, Kunio Ishikawa, Tadashi Kokubo

Research output: Contribution to journalConference articlepeer-review

10 Citations (Scopus)


A newly improved simulated body fluid (n-SBF) was designed to have concentrations of ions equal to those of human blood plasma excepting that of HCO3, the concentration of which is lower than the level of saturation with respect to calcite. The preparation process was modified and two different preparing processes such as powder dissolving and liquid mixing processes were attempted. The n-SBFs with nominal ion concentration can be prepared and its concentrations were unchanged over 4 weeks. The bioactive glasses showed almost same bioactivity in both n-SBFs and c-SBF. The n-SBFs is believed to produce apatite under quite similar condition to the body environment, thereby being useful for in vitro assessment of bioactivity of artificial material.

Original languageEnglish
Pages (from-to)115-118
Number of pages4
JournalKey Engineering Materials
Publication statusPublished - Jan 1 2004
EventThe Annual Meeting of the International Society for Ceramics in Medicine - Porto, Portugal
Duration: Nov 6 2003Nov 9 2003

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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