New pregnane and phenolic glycosides from Solenostemma argel

Karima Ounaissia, David Pertuit, Anne Claire Mitaine-Offer, Tomofumi Miyamoto, Chiaki Tanaka, Stéphanie Delemasure, Patrick Dutartre, Dalila Smati, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


From the aerial parts, pericarps and roots of Solenostemma argel, three new pregnane glycosides (1–3) with two known ones and a new phenolic glycoside (4) have been isolated. Their structures were established by extensive 1D – and 2D NMR and mass spectroscopic analysis. The cytotoxicity of all compounds was evaluated against two human tumor cell lines (SW 480, MCF-7), but none of them was active in the concentration range 0.9–59.0 μM. Compounds 2 and the known argeloside F at non toxic concentrations for the PBMCs (27.3 μM and 27.6 μM, respectively) significantly decreased the Il-1β production by LPS-stimulated PBMCs. All isolated compounds showed a significant antioxidant potential with ORAC values in the concentration range 3481–9617 μmol eq. Trolox/100 g.

Original languageEnglish
Pages (from-to)98-104
Number of pages7
Publication statusPublished - Oct 1 2016

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery


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