TY - JOUR
T1 - New pregnane and phenolic glycosides from Solenostemma argel
AU - Ounaissia, Karima
AU - Pertuit, David
AU - Mitaine-Offer, Anne Claire
AU - Miyamoto, Tomofumi
AU - Tanaka, Chiaki
AU - Delemasure, Stéphanie
AU - Dutartre, Patrick
AU - Smati, Dalila
AU - Lacaille-Dubois, Marie Aleth
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - From the aerial parts, pericarps and roots of Solenostemma argel, three new pregnane glycosides (1–3) with two known ones and a new phenolic glycoside (4) have been isolated. Their structures were established by extensive 1D – and 2D NMR and mass spectroscopic analysis. The cytotoxicity of all compounds was evaluated against two human tumor cell lines (SW 480, MCF-7), but none of them was active in the concentration range 0.9–59.0 μM. Compounds 2 and the known argeloside F at non toxic concentrations for the PBMCs (27.3 μM and 27.6 μM, respectively) significantly decreased the Il-1β production by LPS-stimulated PBMCs. All isolated compounds showed a significant antioxidant potential with ORAC values in the concentration range 3481–9617 μmol eq. Trolox/100 g.
AB - From the aerial parts, pericarps and roots of Solenostemma argel, three new pregnane glycosides (1–3) with two known ones and a new phenolic glycoside (4) have been isolated. Their structures were established by extensive 1D – and 2D NMR and mass spectroscopic analysis. The cytotoxicity of all compounds was evaluated against two human tumor cell lines (SW 480, MCF-7), but none of them was active in the concentration range 0.9–59.0 μM. Compounds 2 and the known argeloside F at non toxic concentrations for the PBMCs (27.3 μM and 27.6 μM, respectively) significantly decreased the Il-1β production by LPS-stimulated PBMCs. All isolated compounds showed a significant antioxidant potential with ORAC values in the concentration range 3481–9617 μmol eq. Trolox/100 g.
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U2 - 10.1016/j.fitote.2016.08.002
DO - 10.1016/j.fitote.2016.08.002
M3 - Article
C2 - 27511059
AN - SCOPUS:84985034339
SN - 0367-326X
VL - 114
SP - 98
EP - 104
JO - Fitoterapia
JF - Fitoterapia
ER -