New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes

Takuma Suzuki; Nanang Rudianto Ariefta; Takuya Koseki; Hiroshi Furuno; Eunsang Kwon; Hiroyuki Momma; Desi Harneti; Rani Maharani; Unang Supratman; Ken ichi Kimura; Yoshihito Shiono

doi:10.1016/j.fitote.2018.11.017

New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes

Takuma Suzuki, Nanang Rudianto Ariefta, Takuya Koseki, Hiroshi Furuno, Eunsang Kwon, Hiroyuki Momma, Desi Harneti, Rani Maharani, Unang Supratman, Ken ichi Kimura, Yoshihito Shiono

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Five polyketides, paralactonic acids A-E (1–5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of compounds 1–5 were determined by comparison of the experimental and calculated ECD spectra. Compound 5 showed moderate antibacterial activity and restored the growth of a mutant yeast strain inhibited by hyperactivated Ca²⁺-signaling.

Original language	English
Pages (from-to)	75-81
Number of pages	7
Journal	Fitoterapia
Volume	132
DOIs	https://doi.org/10.1016/j.fitote.2018.11.017
Publication status	Published - Jan 2019

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

Access to Document

10.1016/j.fitote.2018.11.017

Cite this

Suzuki, T., Ariefta, N. R., Koseki, T., Furuno, H., Kwon, E., Momma, H., Harneti, D., Maharani, R., Supratman, U., Kimura, K. I., & Shiono, Y. (2019). New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes. Fitoterapia, 132, 75-81. https://doi.org/10.1016/j.fitote.2018.11.017

Suzuki, T, Ariefta, NR, Koseki, T, Furuno, H, Kwon, E, Momma, H, Harneti, D, Maharani, R, Supratman, U, Kimura, KI & Shiono, Y 2019, 'New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes', Fitoterapia, vol. 132, pp. 75-81. https://doi.org/10.1016/j.fitote.2018.11.017

@article{467787e52a9e48a5a0073696a1b49ab1,

title = "New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes",

abstract = "Five polyketides, paralactonic acids A-E (1–5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of compounds 1–5 were determined by comparison of the experimental and calculated ECD spectra. Compound 5 showed moderate antibacterial activity and restored the growth of a mutant yeast strain inhibited by hyperactivated Ca2+-signaling.",

author = "Takuma Suzuki and Ariefta, {Nanang Rudianto} and Takuya Koseki and Hiroshi Furuno and Eunsang Kwon and Hiroyuki Momma and Desi Harneti and Rani Maharani and Unang Supratman and Kimura, {Ken ichi} and Yoshihito Shiono",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2019",

month = jan,

doi = "10.1016/j.fitote.2018.11.017",

language = "English",

volume = "132",

pages = "75--81",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier",

}

TY - JOUR

T1 - New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes

AU - Suzuki, Takuma

AU - Ariefta, Nanang Rudianto

AU - Koseki, Takuya

AU - Furuno, Hiroshi

AU - Kwon, Eunsang

AU - Momma, Hiroyuki

AU - Harneti, Desi

AU - Maharani, Rani

AU - Supratman, Unang

AU - Kimura, Ken ichi

AU - Shiono, Yoshihito

PY - 2019/1

Y1 - 2019/1

N2 - Five polyketides, paralactonic acids A-E (1–5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of compounds 1–5 were determined by comparison of the experimental and calculated ECD spectra. Compound 5 showed moderate antibacterial activity and restored the growth of a mutant yeast strain inhibited by hyperactivated Ca2+-signaling.

AB - Five polyketides, paralactonic acids A-E (1–5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of compounds 1–5 were determined by comparison of the experimental and calculated ECD spectra. Compound 5 showed moderate antibacterial activity and restored the growth of a mutant yeast strain inhibited by hyperactivated Ca2+-signaling.

UR - http://www.scopus.com/inward/record.url?scp=85057621571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057621571&partnerID=8YFLogxK

U2 - 10.1016/j.fitote.2018.11.017

DO - 10.1016/j.fitote.2018.11.017

M3 - Article

C2 - 30496810

AN - SCOPUS:85057621571

SN - 0367-326X

VL - 132

SP - 75

EP - 81

JO - Fitoterapia

JF - Fitoterapia

ER -

New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this