Neutrophils scan for activated platelets to initiate inflammation

Vinatha Sreeramkumar, José M. Adrover, Ivan Ballesteros, Maria Isabel Cuartero, Jan Rossaint, Izaskun Bilbao, Maria Nácher, Christophe Pitaval, Irena Radovanovic, Yoshinori Fukui, Rodger P. McEver, Marie Dominique Filippi, Ignacio Lizasoain, Jesús Ruiz-Cabello, Alexander Zarbock, María A. Moro, Andrés Hidalgo

Research output: Contribution to journalArticlepeer-review

470 Citations (Scopus)


Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream.The selectin ligand PSGL-1 transduced signals emanating from these interactions resulting in the redistribution of receptors that drive neutrophil migration. Consequently, neutrophils unable to polarize or to transduce signals through PSGL-1 displayed aberrant crawling and blockade of this domain protected mice against thromboinflammatory injury. These results reveal that recruited neutrophils scan for activated platelets and they suggest that the neutrophils' bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds.

Original languageEnglish
Pages (from-to)1234-1238
Number of pages5
Issue number6214
Publication statusPublished - Dec 5 2014

All Science Journal Classification (ASJC) codes

  • General


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