Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as predictors of wound healing failure in head and neck reconstruction

Yoko Maruyama, Keita Inoue, Keita Mori, Katsuya Gorai, Ryo Shimamoto, Tetsuro Onitsuka, Hiroyoshi Iguchi, Mutsumi Okazaki, Masahiro Nakagawa

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Conclusions: In microsurgical head and neck reconstruction, a higher rate of post-operative wound complication could be predicted by a lower pre-operative neutrophil ratio (< 64.9%), neutrophil-lymphocyte ratio (NLR) (< 3.5), and platelet-lymphocyte ratio (PLR) (< 160). Objectives: To evaluate the predictor of post-operative wound complications in microsurgical head and neck reconstruction. Methods: Patients who were undergoing tumor ablation and microsurgical reconstruction from April 2011 to March 2014 were analyzed retrospectively. The pre-operative hematological data, age, sex, co-morbidities, body mass index (BMI), adjuvant therapies, smoking, operation time, blood loss, total protein, T-stage, and Anesthesiologists Performance Status (ASA-PS) score were collected. Cases of post-operative wound healing failure were reviewed. Results: One hundred and three consecutive patients were enrolled. Among these, the results of 77 patients who were younger than 70 years of age were analyzed. The distributions of the neutrophil ratio (p =.0005), lymphocyte ratio (p =.0166), monocyte ratio (p =.0341), NLR (p =.005), and PLR (p =.008) differed significantly between the patients with and without post-operative wound healing failure. Neutrophil ratio, NLR, and PLR cut-off values of 64.9, 3.5, and 160 were significantly associated with the rate of wound healing failure rate (p =.0002,.00021,.0042, respectively).

Original languageEnglish
Pages (from-to)106-110
Number of pages5
JournalActa Oto-Laryngologica
Issue number1
Publication statusPublished - Jan 2 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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