Neuroscience of emotional memory and posttraumatic stress disorder

Shigenobu Kanba, Koutaro Kudo, Naoko Kaneko, Henny Wati, Hironobu Iguchi, Keiko Takemoto

Research output: Chapter in Book/Report/Conference proceedingChapter


Posttraumatic stress disorder (PTSD) is now widely recognized in Japan followingthe Kobe earthquake and the Tokyo subway sarin poisoning in 1995. Wider awarenessof this disorder has resulted in an increase in the number of patients presentingwith the core symptoms of PTSD, which include: (1) persistent increased arousal;(2) reexperience of a traumatic event; (3) persistent avoidance of stimuli associatedwith the trauma; and (4) numbing of general responsiveness.We have conducted studies to elucidate the biological mechanisms that causethese clinical symptoms and deeply engrain memories associated with highly emotionalevents (emotional memory). We used animal models to target a phenomenoncalled neurogenesis and the dynamics of a gene transcription factor called cyclicAMP-response element binding (CREB) protein in the hippocampus. This chapterdiscusses the results of some of our studies.

Original languageEnglish
Title of host publicationPTSD
Subtitle of host publicationBrain Mechanisms and Clinical Implications
PublisherSpringer Japan
Number of pages7
ISBN (Electronic)9784431295679
ISBN (Print)4431295666, 9784431295662
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • General Agricultural and Biological Sciences
  • General Medicine
  • General Neuroscience


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