Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion

Mai Hazekawa; Aiko Kataoka; Kazuhide Hayakawa; Takeshi Uchimasu; Riyo Furuta; Keiichi Irie; Yoshiharu Akitake; Miyako Yoshida; Toshihiro Fujioka; Nobuaki Egashira; Ryozo Oishi; Kenji Mishima; Kenichi Mishima; Takahiro Uchida; Katunori Iwasaki; Michihiro Fujiwara

doi:10.1248/jhs.56.296

Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion

Mai Hazekawa, Aiko Kataoka, Kazuhide Hayakawa, Takeshi Uchimasu, Riyo Furuta, Keiichi Irie, Yoshiharu Akitake, Miyako Yoshida, Toshihiro Fujioka, Nobuaki Egashira, Ryozo Oishi, Kenji Mishima, Kenichi Mishima, Takahiro Uchida, Katunori Iwasaki, Michihiro Fujiwara

Pharmacy

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Abstract

The neuroprotective effects of Hericium erinaceum (H. erinaceum) were studied in mice subjected to middle cerebral artery (MCA) occlusion. Infarct volumes were markedly reduced in mice receiving 14 days of H. erinaceum (300mg/kg) treatment prior to 4-hr MCA occlusion. Moreover, 14-day pre-ischemic H. erinaceum treatment significantly increased the levels of nerve growth factor (NGF) in both the cortex and striatum of mice subjected to 4-hr MCA occlusion. However, pre-ischemic H erinaceum treatment had no effect on cerebral blood flow (CBF) in the cortex of mice subjected to MCA occlusion. Treatment with H. erinaceum for 1 day prior to MCA occlusion-induced ischemia had no effect on infarct volume or NGF level. These results suggest that 14 days of treatment with H. erinaceum prior to MCA occlusion protected against focal cerebral ischemia, by increasing NGF levels. This implies that H erinaceum and its components could be useful for preventing cerebral infarction.

Original language	English
Pages (from-to)	296-303
Number of pages	8
Journal	Journal of Health Science
Volume	56
Issue number	3
DOIs	https://doi.org/10.1248/jhs.56.296
Publication status	Published - Jun 2010

All Science Journal Classification (ASJC) codes

Toxicology
Health, Toxicology and Mutagenesis

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Hazekawa, M., Kataoka, A., Hayakawa, K., Uchimasu, T., Furuta, R., Irie, K., Akitake, Y., Yoshida, M., Fujioka, T., Egashira, N., Oishi, R., Mishima, K., Mishima, K., Uchida, T., Iwasaki, K., & Fujiwara, M. (2010). Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion. Journal of Health Science, 56(3), 296-303. https://doi.org/10.1248/jhs.56.296

Hazekawa, M, Kataoka, A, Hayakawa, K, Uchimasu, T, Furuta, R, Irie, K, Akitake, Y, Yoshida, M, Fujioka, T, Egashira, N, Oishi, R, Mishima, K, Mishima, K, Uchida, T, Iwasaki, K & Fujiwara, M 2010, 'Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion', Journal of Health Science, vol. 56, no. 3, pp. 296-303. https://doi.org/10.1248/jhs.56.296

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title = "Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion",

abstract = "The neuroprotective effects of Hericium erinaceum (H. erinaceum) were studied in mice subjected to middle cerebral artery (MCA) occlusion. Infarct volumes were markedly reduced in mice receiving 14 days of H. erinaceum (300mg/kg) treatment prior to 4-hr MCA occlusion. Moreover, 14-day pre-ischemic H. erinaceum treatment significantly increased the levels of nerve growth factor (NGF) in both the cortex and striatum of mice subjected to 4-hr MCA occlusion. However, pre-ischemic H erinaceum treatment had no effect on cerebral blood flow (CBF) in the cortex of mice subjected to MCA occlusion. Treatment with H. erinaceum for 1 day prior to MCA occlusion-induced ischemia had no effect on infarct volume or NGF level. These results suggest that 14 days of treatment with H. erinaceum prior to MCA occlusion protected against focal cerebral ischemia, by increasing NGF levels. This implies that H erinaceum and its components could be useful for preventing cerebral infarction.",

author = "Mai Hazekawa and Aiko Kataoka and Kazuhide Hayakawa and Takeshi Uchimasu and Riyo Furuta and Keiichi Irie and Yoshiharu Akitake and Miyako Yoshida and Toshihiro Fujioka and Nobuaki Egashira and Ryozo Oishi and Kenji Mishima and Kenichi Mishima and Takahiro Uchida and Katunori Iwasaki and Michihiro Fujiwara",

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AU - Hazekawa, Mai

AU - Kataoka, Aiko

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AU - Uchimasu, Takeshi

AU - Furuta, Riyo

AU - Irie, Keiichi

AU - Akitake, Yoshiharu

AU - Yoshida, Miyako

AU - Fujioka, Toshihiro

AU - Egashira, Nobuaki

AU - Oishi, Ryozo

AU - Mishima, Kenji

AU - Mishima, Kenichi

AU - Uchida, Takahiro

AU - Iwasaki, Katunori

AU - Fujiwara, Michihiro

PY - 2010/6

Y1 - 2010/6

N2 - The neuroprotective effects of Hericium erinaceum (H. erinaceum) were studied in mice subjected to middle cerebral artery (MCA) occlusion. Infarct volumes were markedly reduced in mice receiving 14 days of H. erinaceum (300mg/kg) treatment prior to 4-hr MCA occlusion. Moreover, 14-day pre-ischemic H. erinaceum treatment significantly increased the levels of nerve growth factor (NGF) in both the cortex and striatum of mice subjected to 4-hr MCA occlusion. However, pre-ischemic H erinaceum treatment had no effect on cerebral blood flow (CBF) in the cortex of mice subjected to MCA occlusion. Treatment with H. erinaceum for 1 day prior to MCA occlusion-induced ischemia had no effect on infarct volume or NGF level. These results suggest that 14 days of treatment with H. erinaceum prior to MCA occlusion protected against focal cerebral ischemia, by increasing NGF levels. This implies that H erinaceum and its components could be useful for preventing cerebral infarction.

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Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion

Abstract

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